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Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality

OBJECTIVES: Deep vein thrombosis (DVT) is a major health-care burden in Europe, but exact estimates are lacking. This study reports results from the PREFER venous thromboembolism (VTE) study concerning health-related quality of life (HrQoL) and mortality of patients with DVT. METHODS: PREFER VTE was...

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Autores principales: Monreal, M., Agnelli, G., Chuang, L. H., Cohen, A. T., Gumbs, P. D., Bauersachs, R., Mismetti, P., Gitt, A. K., Kroep, S., Willich, S. N., Van Hout, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027084/
https://www.ncbi.nlm.nih.gov/pubmed/31840534
http://dx.doi.org/10.1177/1076029619883946
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author Monreal, M.
Agnelli, G.
Chuang, L. H.
Cohen, A. T.
Gumbs, P. D.
Bauersachs, R.
Mismetti, P.
Gitt, A. K.
Kroep, S.
Willich, S. N.
Van Hout, B.
author_facet Monreal, M.
Agnelli, G.
Chuang, L. H.
Cohen, A. T.
Gumbs, P. D.
Bauersachs, R.
Mismetti, P.
Gitt, A. K.
Kroep, S.
Willich, S. N.
Van Hout, B.
author_sort Monreal, M.
collection PubMed
description OBJECTIVES: Deep vein thrombosis (DVT) is a major health-care burden in Europe, but exact estimates are lacking. This study reports results from the PREFER venous thromboembolism (VTE) study concerning health-related quality of life (HrQoL) and mortality of patients with DVT. METHODS: PREFER VTE was a prospective, observational study, conducted in 7 European countries, designed to provide data concerning treatment patterns, resource utilization, mortality, and QoL. First-time or recurrent patients with DVT were followed at 1, 3, 6, and 12 months. Health-related QoL—as measured by the EuroQoL 5-Dimension 5-Level instrument ( EQ-5D-5L)—was analyzed using Tobit regression with repeated measures, assessing the impact of baseline characteristics stratified by cancer activity. Mortality was analyzed using logistic regression. RESULTS: At baseline, patients with DVT had a 0.14 lower EQ-5D-5L index score (0.72 for total sample) compared to the reference UK population (0.85). The EQ-5D-5L index score improved from baseline to 12 months in patients with active cancer (from 0.70 to 0.79) and those without (0.72-0.87); 7.3% died within a year, a 5.2% excess mortality compared to the age- and gender-adfjusted general population. The 12-month mortality rate of DVT varied between 2.9% in the pooled data from Germany, Switzerland, or Austria and 15.4% in Italy. Furthermore, the mortality rate differed between patients with active cancer and those without (42.9% vs 4.7%). CONCLUSIONS: Deep vein thrombosis is associated with a substantial burden of illness in terms of HrQoL at baseline, which following treatment normalizes after 12 months and has a significant mortality rate. In addition, active cancer has a significant impact on mortality and the HrQoL of patients with DVT.
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spelling pubmed-70270842020-02-28 Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality Monreal, M. Agnelli, G. Chuang, L. H. Cohen, A. T. Gumbs, P. D. Bauersachs, R. Mismetti, P. Gitt, A. K. Kroep, S. Willich, S. N. Van Hout, B. Clin Appl Thromb Hemost Impact of Thrombosis on Quality of Life OBJECTIVES: Deep vein thrombosis (DVT) is a major health-care burden in Europe, but exact estimates are lacking. This study reports results from the PREFER venous thromboembolism (VTE) study concerning health-related quality of life (HrQoL) and mortality of patients with DVT. METHODS: PREFER VTE was a prospective, observational study, conducted in 7 European countries, designed to provide data concerning treatment patterns, resource utilization, mortality, and QoL. First-time or recurrent patients with DVT were followed at 1, 3, 6, and 12 months. Health-related QoL—as measured by the EuroQoL 5-Dimension 5-Level instrument ( EQ-5D-5L)—was analyzed using Tobit regression with repeated measures, assessing the impact of baseline characteristics stratified by cancer activity. Mortality was analyzed using logistic regression. RESULTS: At baseline, patients with DVT had a 0.14 lower EQ-5D-5L index score (0.72 for total sample) compared to the reference UK population (0.85). The EQ-5D-5L index score improved from baseline to 12 months in patients with active cancer (from 0.70 to 0.79) and those without (0.72-0.87); 7.3% died within a year, a 5.2% excess mortality compared to the age- and gender-adfjusted general population. The 12-month mortality rate of DVT varied between 2.9% in the pooled data from Germany, Switzerland, or Austria and 15.4% in Italy. Furthermore, the mortality rate differed between patients with active cancer and those without (42.9% vs 4.7%). CONCLUSIONS: Deep vein thrombosis is associated with a substantial burden of illness in terms of HrQoL at baseline, which following treatment normalizes after 12 months and has a significant mortality rate. In addition, active cancer has a significant impact on mortality and the HrQoL of patients with DVT. SAGE Publications 2019-12-16 /pmc/articles/PMC7027084/ /pubmed/31840534 http://dx.doi.org/10.1177/1076029619883946 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Impact of Thrombosis on Quality of Life
Monreal, M.
Agnelli, G.
Chuang, L. H.
Cohen, A. T.
Gumbs, P. D.
Bauersachs, R.
Mismetti, P.
Gitt, A. K.
Kroep, S.
Willich, S. N.
Van Hout, B.
Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title_full Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title_fullStr Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title_full_unstemmed Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title_short Deep Vein Thrombosis in Europe—Health-Related Quality of Life and Mortality
title_sort deep vein thrombosis in europe—health-related quality of life and mortality
topic Impact of Thrombosis on Quality of Life
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027084/
https://www.ncbi.nlm.nih.gov/pubmed/31840534
http://dx.doi.org/10.1177/1076029619883946
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