Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration

BACKGROUND: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known mark...

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Autores principales: Matsuura, Toshiyuki, Kaneko, Hiroki, Takayama, Kei, Shibata, Rei, Kataoka, Keiko, Ito, Seina, Tsunekawa, Taichi, Shimizu, Hideyuki, Suzumura, Ayana, Namba, Rina, Ito, Yasuki, Murohara, Toyoaki, Terasaki, Hiroko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027115/
https://www.ncbi.nlm.nih.gov/pubmed/32070305
http://dx.doi.org/10.1186/s12886-020-01334-y
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author Matsuura, Toshiyuki
Kaneko, Hiroki
Takayama, Kei
Shibata, Rei
Kataoka, Keiko
Ito, Seina
Tsunekawa, Taichi
Shimizu, Hideyuki
Suzumura, Ayana
Namba, Rina
Ito, Yasuki
Murohara, Toyoaki
Terasaki, Hiroko
author_facet Matsuura, Toshiyuki
Kaneko, Hiroki
Takayama, Kei
Shibata, Rei
Kataoka, Keiko
Ito, Seina
Tsunekawa, Taichi
Shimizu, Hideyuki
Suzumura, Ayana
Namba, Rina
Ito, Yasuki
Murohara, Toyoaki
Terasaki, Hiroko
author_sort Matsuura, Toshiyuki
collection PubMed
description BACKGROUND: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. METHODS: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. RESULTS: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). CONCLUSION: The d-ROMs test may provide a useful indicator of nAMD in men but not in women.
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spelling pubmed-70271152020-02-24 Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration Matsuura, Toshiyuki Kaneko, Hiroki Takayama, Kei Shibata, Rei Kataoka, Keiko Ito, Seina Tsunekawa, Taichi Shimizu, Hideyuki Suzumura, Ayana Namba, Rina Ito, Yasuki Murohara, Toyoaki Terasaki, Hiroko BMC Ophthalmol Research Article BACKGROUND: Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD. METHODS: Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined. RESULTS: In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (312.0 ± 52.4 vs. 275.1 ± 45.5 U.CARR, respectively; P < .05). There was a significant correlation between d-ROM level and CNV lesion area in the male nAMD group (r = .42, P = .05). There were no significant differences in mean BAP test results between the nAMD patients and controls for either sex (men: 2241 ± 549 vs. 2136 ± 246 μmol/L; women: 2263 ± 292 vs. 2335 ± 161 μmol/L). CONCLUSION: The d-ROMs test may provide a useful indicator of nAMD in men but not in women. BioMed Central 2020-02-18 /pmc/articles/PMC7027115/ /pubmed/32070305 http://dx.doi.org/10.1186/s12886-020-01334-y Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Matsuura, Toshiyuki
Kaneko, Hiroki
Takayama, Kei
Shibata, Rei
Kataoka, Keiko
Ito, Seina
Tsunekawa, Taichi
Shimizu, Hideyuki
Suzumura, Ayana
Namba, Rina
Ito, Yasuki
Murohara, Toyoaki
Terasaki, Hiroko
Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title_full Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title_fullStr Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title_full_unstemmed Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title_short Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
title_sort diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027115/
https://www.ncbi.nlm.nih.gov/pubmed/32070305
http://dx.doi.org/10.1186/s12886-020-01334-y
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