Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis

BACKGROUND: Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc in other models of OS. METHODS: We created a rat PCOS model with increased OS le...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Daojuan, Wang, Tingyu, Wang, Rong, Zhang, Xinlin, Wang, Lei, Xiang, Zou, Zhuang, Lingjia, Shen, Shanmei, Wang, Hongwei, Gao, Qian, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027222/
https://www.ncbi.nlm.nih.gov/pubmed/32066482
http://dx.doi.org/10.1186/s12967-020-02249-4

Ejemplares similares

Ejemplares similares