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The mode of action of Fruitless: Is it an easy matter to switch the sex?
The fruitless (fru) locus was originally defined by a male sterile mutation that promotes male‐to‐male courtship while suppressing male‐to‐female courtship in Drosophila melanogaster. The fru promoter‐1 pre‐RNA generates a set of BTB‐zinc finger family FruM proteins expressed exclusively in the male...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027472/ https://www.ncbi.nlm.nih.gov/pubmed/31420927 http://dx.doi.org/10.1111/gbb.12606 |
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author | Sato, Kosei Yamamoto, Daisuke |
author_facet | Sato, Kosei Yamamoto, Daisuke |
author_sort | Sato, Kosei |
collection | PubMed |
description | The fruitless (fru) locus was originally defined by a male sterile mutation that promotes male‐to‐male courtship while suppressing male‐to‐female courtship in Drosophila melanogaster. The fru promoter‐1 pre‐RNA generates a set of BTB‐zinc finger family FruM proteins expressed exclusively in the male neurons, leading to the formation of sexual dimorphisms in neurons via male‐specific neuroblast proliferation, male‐specific neural survival, male‐specific neuritegenesis or male‐specific arbor patterning. Such a wide spectrum of phenotypic effects seems to result from chromatin modifications, in which FruBM recruits Bonus, Histone deacetylase 1 (HDAC1) and/or Heterochromatin protein 1a (HP1a) to ~130 target sites. One established FruBM transcriptional target is the axon guidance protein gene robo1. Multiple transcriptional regulator‐binding sites are nested around the FruBM‐binding site, and mediate sophisticated modulation of the repressor activity of FruBM. FruBM also binds to the Lola‐Q transcriptional repressor to protect it from proteasome‐dependent degradation in male but not female neurons as FruBM exists only in male neurons, leading to the formation of sexually dimorphic neural structures. These findings shed light on the multilayered network of transcription regulation orchestrated by the master regulator FruBM. |
format | Online Article Text |
id | pubmed-7027472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70274722020-02-24 The mode of action of Fruitless: Is it an easy matter to switch the sex? Sato, Kosei Yamamoto, Daisuke Genes Brain Behav Reviews The fruitless (fru) locus was originally defined by a male sterile mutation that promotes male‐to‐male courtship while suppressing male‐to‐female courtship in Drosophila melanogaster. The fru promoter‐1 pre‐RNA generates a set of BTB‐zinc finger family FruM proteins expressed exclusively in the male neurons, leading to the formation of sexual dimorphisms in neurons via male‐specific neuroblast proliferation, male‐specific neural survival, male‐specific neuritegenesis or male‐specific arbor patterning. Such a wide spectrum of phenotypic effects seems to result from chromatin modifications, in which FruBM recruits Bonus, Histone deacetylase 1 (HDAC1) and/or Heterochromatin protein 1a (HP1a) to ~130 target sites. One established FruBM transcriptional target is the axon guidance protein gene robo1. Multiple transcriptional regulator‐binding sites are nested around the FruBM‐binding site, and mediate sophisticated modulation of the repressor activity of FruBM. FruBM also binds to the Lola‐Q transcriptional repressor to protect it from proteasome‐dependent degradation in male but not female neurons as FruBM exists only in male neurons, leading to the formation of sexually dimorphic neural structures. These findings shed light on the multilayered network of transcription regulation orchestrated by the master regulator FruBM. Blackwell Publishing Ltd 2019-09-05 2020-02 /pmc/articles/PMC7027472/ /pubmed/31420927 http://dx.doi.org/10.1111/gbb.12606 Text en © 2019 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Sato, Kosei Yamamoto, Daisuke The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title | The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title_full | The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title_fullStr | The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title_full_unstemmed | The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title_short | The mode of action of Fruitless: Is it an easy matter to switch the sex? |
title_sort | mode of action of fruitless: is it an easy matter to switch the sex? |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027472/ https://www.ncbi.nlm.nih.gov/pubmed/31420927 http://dx.doi.org/10.1111/gbb.12606 |
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