Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial

BACKGROUND: Narrowband UVB phototherapy (NB‐UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB‐UVB treatment increases 25‐hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate an...

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Autores principales: Weber, B., Marculescu, R., Radakovic, S., Tanew, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Photodermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027503/
https://www.ncbi.nlm.nih.gov/pubmed/31494977
http://dx.doi.org/10.1111/jdv.15941
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author Weber, B.
Marculescu, R.
Radakovic, S.
Tanew, A.
author_facet Weber, B.
Marculescu, R.
Radakovic, S.
Tanew, A.
author_sort Weber, B.
collection PubMed
description BACKGROUND: Narrowband UVB phototherapy (NB‐UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB‐UVB treatment increases 25‐hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate and cobalamin. OBJECTIVES: To determine whether exposure to NB‐UVB alters serum folate or cobalamin levels. METHODS: A single‐centre, prospective, open observational study on 101 patients subjected to NB‐UVB phototherapy between late fall and early spring. Serum folate, 25(OH)D and cobalamin levels were measured after 0, 12, 24 and 36 NB‐UVB exposures. RESULTS: After 12 NB‐UVB exposures a significant decrease of mean serum folate (−1.0 nmol/L; P = 0.03) and cobalamin (−14.5 pmol/L, P = 0.03) levels was observed whereas serum levels of 25(OH)D showed a significant increase (35.4 nmol/L, P < 0.0001). CONCLUSIONS: A standard course of NB‐UVB induces a small but significant decrease of serum folate and cobalamin levels.
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spelling pubmed-70275032020-02-24 Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial Weber, B. Marculescu, R. Radakovic, S. Tanew, A. J Eur Acad Dermatol Venereol Photodermatology BACKGROUND: Narrowband UVB phototherapy (NB‐UVB) is a mainstay in the treatment of numerous inflammatory dermatoses. Whereas, a wealth of studies has shown that NB‐UVB treatment increases 25‐hydroxyvitamin D3 (25(OH)D) levels, only sparse and controversial data exist on its effect on serum folate and cobalamin. OBJECTIVES: To determine whether exposure to NB‐UVB alters serum folate or cobalamin levels. METHODS: A single‐centre, prospective, open observational study on 101 patients subjected to NB‐UVB phototherapy between late fall and early spring. Serum folate, 25(OH)D and cobalamin levels were measured after 0, 12, 24 and 36 NB‐UVB exposures. RESULTS: After 12 NB‐UVB exposures a significant decrease of mean serum folate (−1.0 nmol/L; P = 0.03) and cobalamin (−14.5 pmol/L, P = 0.03) levels was observed whereas serum levels of 25(OH)D showed a significant increase (35.4 nmol/L, P < 0.0001). CONCLUSIONS: A standard course of NB‐UVB induces a small but significant decrease of serum folate and cobalamin levels. John Wiley and Sons Inc. 2019-10-08 2020-02 /pmc/articles/PMC7027503/ /pubmed/31494977 http://dx.doi.org/10.1111/jdv.15941 Text en © 2019 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Photodermatology
Weber, B.
Marculescu, R.
Radakovic, S.
Tanew, A.
Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title_full Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title_fullStr Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title_full_unstemmed Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title_short Serum levels of folate, 25‐hydroxyvitamin D3 and cobalamin during UVB phototherapy: findings in a large prospective trial
title_sort serum levels of folate, 25‐hydroxyvitamin d3 and cobalamin during uvb phototherapy: findings in a large prospective trial
topic Photodermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027503/
https://www.ncbi.nlm.nih.gov/pubmed/31494977
http://dx.doi.org/10.1111/jdv.15941
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AT radakovics serumlevelsoffolate25hydroxyvitamind3andcobalaminduringuvbphototherapyfindingsinalargeprospectivetrial
AT tanewa serumlevelsoffolate25hydroxyvitamind3andcobalaminduringuvbphototherapyfindingsinalargeprospectivetrial

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