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Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol

We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity poly...

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Detalles Bibliográficos
Autores principales: Liu, Weifeng, Holdsworth, Clovia, Ye, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027874/
https://www.ncbi.nlm.nih.gov/pubmed/31930590
http://dx.doi.org/10.1002/chir.23167
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author Liu, Weifeng
Holdsworth, Clovia
Ye, Lei
author_facet Liu, Weifeng
Holdsworth, Clovia
Ye, Lei
author_sort Liu, Weifeng
collection PubMed
description We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors.
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spelling pubmed-70278742020-02-24 Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol Liu, Weifeng Holdsworth, Clovia Ye, Lei Chirality Regular Articles We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors. John Wiley and Sons Inc. 2020-01-13 2020-03 /pmc/articles/PMC7027874/ /pubmed/31930590 http://dx.doi.org/10.1002/chir.23167 Text en © 2020 The Authors. Chirality published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Articles
Liu, Weifeng
Holdsworth, Clovia
Ye, Lei
Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title_full Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title_fullStr Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title_full_unstemmed Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title_short Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
title_sort synthesis of molecularly imprinted polymers using a functionalized initiator for chiral‐selective recognition of propranolol
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027874/
https://www.ncbi.nlm.nih.gov/pubmed/31930590
http://dx.doi.org/10.1002/chir.23167
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