Hepatitis B Virus Virions Produced Under Nucleos(t)ide Analogue Treatment Are Mainly Not Infectious Because of Irreversible DNA Chain Termination

Nucleos(t)ide analogues (NAs) have been widely used for the treatment of chronic hepatitis B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease activity), theoretically, the incorporated NAs would irreversibly terminate viral DNA synthesis. This study explored the nature...

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Detalles Bibliográficos
Autores principales: Liu, Yongzhen, Liu, Hui, Hu, Zhanying, Ding, Yang, Pan, Xiao‐Ben, Zou, Jun, Xi, Jingyuan, Yu, Guangxin, Huang, Hongxin, Luo, Meng‐Ting, Guo, Fang, Liu, Shuang, Sheng, Qiuju, Jia, Jidong, Zheng, Yong‐Tang, Wang, Jie, Chen, Xiangmei, Guo, Ju‐Tao, Wei, Lai, Lu, Fengmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028043/
https://www.ncbi.nlm.nih.gov/pubmed/31278760
http://dx.doi.org/10.1002/hep.30844

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