The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances

In vitro assays presently used for prenatal developmental toxicity (PDT) testing only assess the embryotoxic potential of parent substances and not that of potentially embryotoxic metabolites. Here we combined a biotransformation system, using hamster liver microsomes, with the ES‐D3 cell differenti...

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Detalles Bibliográficos
Autores principales: Kamelia, Lenny, de Haan, Laura, Spenkelink, Bert, Bruyneel, Ben, Ketelslegers, Hans B., Boogaard, Peter J., Rietjens, Ivonne M.C.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028058/
https://www.ncbi.nlm.nih.gov/pubmed/31808176
http://dx.doi.org/10.1002/jat.3906

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