Polymer Nanocontainers for Intracellular Delivery

Carriers for intracellular delivery are required to overcome limitations of therapeutic agents such as low specificity, systemic toxicity, high clearance rate, and low therapeutic index. Nanocontainers comprised of an aqueous core and a polymer shell have received increasing attention because they r...

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Detalles Bibliográficos
Autores principales: Pottanam Chali, Sharafudheen, Ravoo, Bart Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028112/
https://www.ncbi.nlm.nih.gov/pubmed/31364243
http://dx.doi.org/10.1002/anie.201907484
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author Pottanam Chali, Sharafudheen
Ravoo, Bart Jan
author_facet Pottanam Chali, Sharafudheen
Ravoo, Bart Jan
author_sort Pottanam Chali, Sharafudheen
collection PubMed
description Carriers for intracellular delivery are required to overcome limitations of therapeutic agents such as low specificity, systemic toxicity, high clearance rate, and low therapeutic index. Nanocontainers comprised of an aqueous core and a polymer shell have received increasing attention because they readily combine stimuli response to improve intracellular payload release and surface modification to enhance selectivity towards the desired region of action. This Minireview summarizes the design and properties of polymer nanocontainers for intracellular delivery, classified according to the polymer architecture.
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spelling pubmed-70281122020-02-25 Polymer Nanocontainers for Intracellular Delivery Pottanam Chali, Sharafudheen Ravoo, Bart Jan Angew Chem Int Ed Engl Minireviews Carriers for intracellular delivery are required to overcome limitations of therapeutic agents such as low specificity, systemic toxicity, high clearance rate, and low therapeutic index. Nanocontainers comprised of an aqueous core and a polymer shell have received increasing attention because they readily combine stimuli response to improve intracellular payload release and surface modification to enhance selectivity towards the desired region of action. This Minireview summarizes the design and properties of polymer nanocontainers for intracellular delivery, classified according to the polymer architecture. John Wiley and Sons Inc. 2019-10-31 2020-02-17 /pmc/articles/PMC7028112/ /pubmed/31364243 http://dx.doi.org/10.1002/anie.201907484 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Minireviews
Pottanam Chali, Sharafudheen
Ravoo, Bart Jan
Polymer Nanocontainers for Intracellular Delivery
title Polymer Nanocontainers for Intracellular Delivery
title_full Polymer Nanocontainers for Intracellular Delivery
title_fullStr Polymer Nanocontainers for Intracellular Delivery
title_full_unstemmed Polymer Nanocontainers for Intracellular Delivery
title_short Polymer Nanocontainers for Intracellular Delivery
title_sort polymer nanocontainers for intracellular delivery
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028112/
https://www.ncbi.nlm.nih.gov/pubmed/31364243
http://dx.doi.org/10.1002/anie.201907484
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