Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes

Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionall...

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Detalles Bibliográficos
Autores principales: Cao, Zhao-Hui, Wu, Zhuan, Hu, Cong, Zhang, Min, Wang, Wu-Zhou, Hu, Xiao-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028193/
https://www.ncbi.nlm.nih.gov/pubmed/31923106
http://dx.doi.org/10.1097/CM9.0000000000000583
Descripción
Sumario:Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D.

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