Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes

Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionall...

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Autores principales: Cao, Zhao-Hui, Wu, Zhuan, Hu, Cong, Zhang, Min, Wang, Wu-Zhou, Hu, Xiao-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028193/
https://www.ncbi.nlm.nih.gov/pubmed/31923106
http://dx.doi.org/10.1097/CM9.0000000000000583
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author Cao, Zhao-Hui
Wu, Zhuan
Hu, Cong
Zhang, Min
Wang, Wu-Zhou
Hu, Xiao-Bo
author_facet Cao, Zhao-Hui
Wu, Zhuan
Hu, Cong
Zhang, Min
Wang, Wu-Zhou
Hu, Xiao-Bo
author_sort Cao, Zhao-Hui
collection PubMed
description Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D.
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spelling pubmed-70281932020-03-10 Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes Cao, Zhao-Hui Wu, Zhuan Hu, Cong Zhang, Min Wang, Wu-Zhou Hu, Xiao-Bo Chin Med J (Engl) Review Article Type 1 diabetes (T1D) results from dysfunction of pancreatic islets β cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic β cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. Studies have shown that severe ER stress is directly involved in the pancreatic β cells destruction and pathogenesis of T1D. ER stress plays a key part in pancreatic β cells and T1D, which will help in developing new effective therapeutics for T1D. Wolters Kluwer Health 2020-01-05 2020-01-05 /pmc/articles/PMC7028193/ /pubmed/31923106 http://dx.doi.org/10.1097/CM9.0000000000000583 Text en Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Review Article
Cao, Zhao-Hui
Wu, Zhuan
Hu, Cong
Zhang, Min
Wang, Wu-Zhou
Hu, Xiao-Bo
Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title_full Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title_fullStr Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title_full_unstemmed Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title_short Endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
title_sort endoplasmic reticulum stress and destruction of pancreatic β cells in type 1 diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028193/
https://www.ncbi.nlm.nih.gov/pubmed/31923106
http://dx.doi.org/10.1097/CM9.0000000000000583
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