Cargando…

Quantitative proteomic analysis reveals that Luks-PV exerts antitumor activity by regulating the key proteins and metabolic pathways in HepG2 cells

Hepatocellular carcinoma (HCC) is a complicated and poor prognosis cancer, necessitating the development of a potential treatment strategy. In this study, we initially revealed that LukS-PV belonged to leukocidin family performs an anti-HCC action. Then, we used liquid chromatography-mass spectromet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Chang-Cheng, Yu, Wen-Wei, Qi, Ying-Jie, Xu, Liang-Fei, Wang, Zi-Ran, Qiang, Ya-Wen, Ma, Fan, Ma, Xiao-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Preclinical Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028286/ https://www.ncbi.nlm.nih.gov/pubmed/31789624 http://dx.doi.org/10.1097/CAD.0000000000000866

Ejemplares similares

Engineering of the LukS-PV and LukF-PV subunits of Staphylococcus aureus Panton-Valentine leukocidin for Diagnostic and Therapeutic Applications
por: Okolie, Charles Emeka, et al.
Publicado: (2013)

Structurally Designed Attenuated Subunit Vaccines for S. aureus LukS-PV and LukF-PV Confer Protection in a Mouse Bacteremia Model
por: Karauzum, Hatice, et al.
Publicado: (2013)

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression
por: Wang, Ziran, et al.
Publicado: (2020)

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression
por: Wang, Ziran, et al.
Publicado: (2020)

LukS‐PV induces apoptosis in acute myeloid leukemia cells mediated by C5a receptor
por: Zhang, Peng, et al.
Publicado: (2019)

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression
por: Xu, Xuexue, et al.
Publicado: (2022)

Antibiotic susceptibility profile and prevalence of mecA and lukS-PV/lukF-PV genes in Staphylococcus aureus isolated from nasal and pharyngeal sources of medical students in Ecuador
por: Bastidas, Carlos A, et al.
Publicado: (2019)

The anticancer effect of recombinant LukS-PV protein and silver nanoparticles loaded with this protein
por: Haghighatafshar, Hafizeh, et al.
Publicado: (2023)

Infliximab Exerts No Direct Hepatotoxic Effect on HepG2 Cells In Vitro
por: de Vries, Hilbert S., et al.
Publicado: (2012)

LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis
por: Ma, Fan, et al.
Publicado: (2020)

Cholesterol-lowing effect of taurine in HepG2 cell
por: Guo, Junxia, et al.
Publicado: (2017)

Effects of Erythrodiol on the Antioxidant Response and Proteome of HepG2 Cells
por: Peñas-Fuentes, Juan Luis, et al.
Publicado: (2021)

Effects of dehydroabietic acid on nontarget lipidomics and proteomics of HepG2
por: Xiahou, Zhikai, et al.
Publicado: (2022)

Overexpression of activating transcription factor 3 exerts suppressive effects in HepG2 cells
por: Li, Xiaoyan, et al.
Publicado: (2019)

Increased Age-Dependent Risk of Death Associated With lukF-PV-Positive Staphylococcus aureus Bacteremia
por: Knudsen, Trine A., et al.
Publicado: (2016)

Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line
por: ZHANG, HUI, et al.
Publicado: (2014)

Separately or Combined, LukG/LukH Is Functionally Unique Compared to Other Staphylococcal Bicomponent Leukotoxins
por: Yanai, Machi, et al.
Publicado: (2014)

A proteomic analysis of mushroom polysaccharide-treated HepG2 cells
por: Chai, Yangyang, et al.
Publicado: (2016)

Antitumor activity of recombinant RGD-IFN-α2a-core fusion protein in vitro
por: Wen, Zhengwei, et al.
Publicado: (2017)

Unraveling the in vitro antitumor activity of Vismia baccifera against HepG2: role of hydrogen peroxide
por: Trepiana, Jenifer, et al.
Publicado: (2018)

iTRAQ-Based Quantitative Proteomics Reveals the Energy Metabolism Alterations Induced by Chlorogenic Acid in HepG2 Cells
por: Takahashi, Shoko, et al.
Publicado: (2022)

Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction
por: Roel, María, et al.
Publicado: (2015)

Naringenin and Quercetin Exert Contradictory Cytoprotective and Cytotoxic Effects on Tamoxifen-Induced Apoptosis in HepG2 Cells
por: Xu, Zhixiang, et al.
Publicado: (2022)

LukS-PV Induces Apoptosis via the SET8-H4K20me1-PIK3CB Axis in Human Acute Myeloid Leukemia Cells
por: Xu, Liang Fei, et al.
Publicado: (2021)

Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array
por: Yumnam, Silvia, et al.
Publicado: (2017)

Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells
por: Xin, Zhonghao, et al.
Publicado: (2017)

Knockdown of nucleophosmin induces S-phase arrest in HepG2 cells
por: Wang, Qing-Qing, et al.
Publicado: (2011)

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells
por: Dai, Zhi-Jun, et al.
Publicado: (2013)

Typing of Panton-Valentine Leukocidin-Encoding Phages and lukSF-PV Gene Sequence Variation in Staphylococcus aureus from China
por: Zhao, Huanqiang, et al.
Publicado: (2016)

Ginkgolide C reduced oleic acid-induced lipid accumulation in HepG2 cells
por: Huang, Wen-Chung, et al.
Publicado: (2018)

Artificial cells eavesdropping on HepG2 cells
por: Westensee, Isabella Nymann, et al.
Publicado: (2023)

NaHCO(3) enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
por: Yuan, Ya Hong, et al.
Publicado: (2016)

iTRAQ-Based Quantitative Proteomic Analysis of the Inhibitory Effects of Polysaccharides from Viscum coloratum (Kom.) Nakai on HepG2 Cells
por: Chai, Yangyang, et al.
Publicado: (2017)

Proteomic analysis of the inhibitory effect of epigallocatechin gallate on lipid accumulation in human HepG2 cells
por: Liu, Zhonghua, et al.
Publicado: (2013)

Proteomics Based Identification of Cell Migration Related Proteins in HBV Expressing HepG2 Cells
por: Feng, Huixing, et al.
Publicado: (2014)

Global Proteomics to Study Silica Nanoparticle-Induced Cytotoxicity and Its Mechanisms in HepG2 Cells
por: Lee, Sun Young, et al.
Publicado: (2021)

Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture
por: Ellero, Andrea Antonio, et al.
Publicado: (2021)

Antibodies to S. aureus LukS-PV Attenuated Subunit Vaccine Neutralize a Broad Spectrum of Canonical and Non-Canonical Bicomponent Leukotoxin Pairs
por: Adhikari, Rajan P., et al.
Publicado: (2015)

Delisheng, a Chinese medicinal compound, exerts anti-proliferative and pro-apoptotic effects on HepG2 cells through extrinsic and intrinsic pathways
por: Lu, Chuang-xin, et al.
Publicado: (2009)

Lactic Acid Bacteria Exert a Hepatoprotective Effect against Ethanol-Induced Liver Injury in HepG2 Cells
por: Lee, Ji Yeon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_te0ve7oh6arc5qo1245a7id3dj