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Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028288/ https://www.ncbi.nlm.nih.gov/pubmed/32069304 http://dx.doi.org/10.1371/journal.pone.0229152 |
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author | Campolo, Jonica Corradi, Ettore Rizzardi, Alice Parolini, Marina Dellanoce, Cinzia Di Guglielmo, Maria Luisa Tarlarini, Patrizia Cattaneo, Marina Trivella, Maria Giovanna De Maria, Renata |
author_facet | Campolo, Jonica Corradi, Ettore Rizzardi, Alice Parolini, Marina Dellanoce, Cinzia Di Guglielmo, Maria Luisa Tarlarini, Patrizia Cattaneo, Marina Trivella, Maria Giovanna De Maria, Renata |
author_sort | Campolo, Jonica |
collection | PubMed |
description | Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m(2), we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105–198]) vs 83 [33–115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women. |
format | Online Article Text |
id | pubmed-7028288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-70282882020-02-27 Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging Campolo, Jonica Corradi, Ettore Rizzardi, Alice Parolini, Marina Dellanoce, Cinzia Di Guglielmo, Maria Luisa Tarlarini, Patrizia Cattaneo, Marina Trivella, Maria Giovanna De Maria, Renata PLoS One Research Article Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m(2), we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105–198]) vs 83 [33–115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women. Public Library of Science 2020-02-18 /pmc/articles/PMC7028288/ /pubmed/32069304 http://dx.doi.org/10.1371/journal.pone.0229152 Text en © 2020 Campolo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Campolo, Jonica Corradi, Ettore Rizzardi, Alice Parolini, Marina Dellanoce, Cinzia Di Guglielmo, Maria Luisa Tarlarini, Patrizia Cattaneo, Marina Trivella, Maria Giovanna De Maria, Renata Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title | Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title_full | Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title_fullStr | Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title_full_unstemmed | Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title_short | Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging |
title_sort | irisin and markers of metabolic derangement in non-diabetic caucasian subjects with stage i-ii obesity during early aging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028288/ https://www.ncbi.nlm.nih.gov/pubmed/32069304 http://dx.doi.org/10.1371/journal.pone.0229152 |
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