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Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging

Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic...

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Autores principales: Campolo, Jonica, Corradi, Ettore, Rizzardi, Alice, Parolini, Marina, Dellanoce, Cinzia, Di Guglielmo, Maria Luisa, Tarlarini, Patrizia, Cattaneo, Marina, Trivella, Maria Giovanna, De Maria, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028288/
https://www.ncbi.nlm.nih.gov/pubmed/32069304
http://dx.doi.org/10.1371/journal.pone.0229152
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author Campolo, Jonica
Corradi, Ettore
Rizzardi, Alice
Parolini, Marina
Dellanoce, Cinzia
Di Guglielmo, Maria Luisa
Tarlarini, Patrizia
Cattaneo, Marina
Trivella, Maria Giovanna
De Maria, Renata
author_facet Campolo, Jonica
Corradi, Ettore
Rizzardi, Alice
Parolini, Marina
Dellanoce, Cinzia
Di Guglielmo, Maria Luisa
Tarlarini, Patrizia
Cattaneo, Marina
Trivella, Maria Giovanna
De Maria, Renata
author_sort Campolo, Jonica
collection PubMed
description Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m(2), we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105–198]) vs 83 [33–115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women.
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spelling pubmed-70282882020-02-27 Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging Campolo, Jonica Corradi, Ettore Rizzardi, Alice Parolini, Marina Dellanoce, Cinzia Di Guglielmo, Maria Luisa Tarlarini, Patrizia Cattaneo, Marina Trivella, Maria Giovanna De Maria, Renata PLoS One Research Article Irisin concentrations are decreased in subjects with overt diabetes and upregulated in those with obesity or impaired fasting glucose. However, gender-balanced data in older populations, in whom risk factors commonly culminate in overt cardiovascular disease, are scarce. We assessed in non-diabetic Caucasian subjects with stage I-II obesity in the early aging range (50 to 70 years), the relationship between irisin, body composition and markers of metabolic derangement by gender. In 60 (31 women, 29 men) non-diabetics with a body mass index ≥30 - ≤40 kg/m(2), we measured anthropometrics and body composition (Air Displacement Plethysmography). We assayed lipid and glucose profile by routine methods, plasma irisin by ELISA and measured insulin resistance by the HOMA index. Irisin levels were higher in women than in men (161 [105–198]) vs 83 [33–115] ng/ml, P<0.001), and correlated directly with HOMA index in both (rho 0.735, P<0.001 M, rho 0.452, P = 0.011 F). Sex differences were maintained across insulin resistance severity stages. In men, irisin concentrations correlated directly with body mass index (rho 0.755, P<0.001), waist circumference (rho 0.623, P<0.001), fat mass index (rho 0.762, P<0.001), glucose (rho 0.408, P = 0.028), the fatty liver index (rho 0.705, P<0.001) and FINDRISC score (rho 0.536, P = 0.003). Among non-diabetic Caucasian subjects with obesity in the early stages of aging, irisin levels reflect the amount of body fat and insulin resistance severity, independently of between-gender differences in the adipomyokine concentrations and are associated with markers of visceral adiposity in men but not in women. Public Library of Science 2020-02-18 /pmc/articles/PMC7028288/ /pubmed/32069304 http://dx.doi.org/10.1371/journal.pone.0229152 Text en © 2020 Campolo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Campolo, Jonica
Corradi, Ettore
Rizzardi, Alice
Parolini, Marina
Dellanoce, Cinzia
Di Guglielmo, Maria Luisa
Tarlarini, Patrizia
Cattaneo, Marina
Trivella, Maria Giovanna
De Maria, Renata
Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title_full Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title_fullStr Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title_full_unstemmed Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title_short Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging
title_sort irisin and markers of metabolic derangement in non-diabetic caucasian subjects with stage i-ii obesity during early aging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028288/
https://www.ncbi.nlm.nih.gov/pubmed/32069304
http://dx.doi.org/10.1371/journal.pone.0229152
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