Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system

Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncogenic signaling networks, is frequently activated in...

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Detalles Bibliográficos
Autores principales: Klarenbeek, Sjoerd, Doornebal, Chris W., Kas, Sjors M., Bonzanni, Nicola, Bhin, Jinhyuk, Braumuller, Tanya M., van der Heijden, Ingrid, Opdam, Mark, Schouten, Philip C., Kersten, Kelly, de Bruijn, Roebi, Zingg, Daniel, Yemelyanenko, Julia, Wessels, Lodewyk F.A., de Visser, Karin E., Jonkers, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028325/
https://www.ncbi.nlm.nih.gov/pubmed/32117586
http://dx.doi.org/10.1080/2162402X.2020.1724049

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