Metabolism in the tumor microenvironment: insights from single-cell analysis

The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single ce...

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Detalles Bibliográficos
Autores principales: Xiao, Zhengtao, Locasale, Jason W., Dai, Ziwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028342/
https://www.ncbi.nlm.nih.gov/pubmed/32117592
http://dx.doi.org/10.1080/2162402X.2020.1726556
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author Xiao, Zhengtao
Locasale, Jason W.
Dai, Ziwei
author_facet Xiao, Zhengtao
Locasale, Jason W.
Dai, Ziwei
author_sort Xiao, Zhengtao
collection PubMed
description The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.
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spelling pubmed-70283422020-02-28 Metabolism in the tumor microenvironment: insights from single-cell analysis Xiao, Zhengtao Locasale, Jason W. Dai, Ziwei Oncoimmunology Commentary The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy. Taylor & Francis 2020-02-09 /pmc/articles/PMC7028342/ /pubmed/32117592 http://dx.doi.org/10.1080/2162402X.2020.1726556 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Xiao, Zhengtao
Locasale, Jason W.
Dai, Ziwei
Metabolism in the tumor microenvironment: insights from single-cell analysis
title Metabolism in the tumor microenvironment: insights from single-cell analysis
title_full Metabolism in the tumor microenvironment: insights from single-cell analysis
title_fullStr Metabolism in the tumor microenvironment: insights from single-cell analysis
title_full_unstemmed Metabolism in the tumor microenvironment: insights from single-cell analysis
title_short Metabolism in the tumor microenvironment: insights from single-cell analysis
title_sort metabolism in the tumor microenvironment: insights from single-cell analysis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028342/
https://www.ncbi.nlm.nih.gov/pubmed/32117592
http://dx.doi.org/10.1080/2162402X.2020.1726556
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AT locasalejasonw metabolisminthetumormicroenvironmentinsightsfromsinglecellanalysis
AT daiziwei metabolisminthetumormicroenvironmentinsightsfromsinglecellanalysis

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