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Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body
In order to represent complex stimuli, principle neurons of associative learning regions receive combinatorial sensory inputs. Density of combinatorial innervation is theorized to determine the number of distinct stimuli that can be represented and distinguished from one another, with sparse innerva...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028369/ https://www.ncbi.nlm.nih.gov/pubmed/31913123 http://dx.doi.org/10.7554/eLife.52278 |
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author | Elkahlah, Najia A Rogow, Jackson A Ahmed, Maria Clowney, E Josephine |
author_facet | Elkahlah, Najia A Rogow, Jackson A Ahmed, Maria Clowney, E Josephine |
author_sort | Elkahlah, Najia A |
collection | PubMed |
description | In order to represent complex stimuli, principle neurons of associative learning regions receive combinatorial sensory inputs. Density of combinatorial innervation is theorized to determine the number of distinct stimuli that can be represented and distinguished from one another, with sparse innervation thought to optimize the complexity of representations in networks of limited size. How the convergence of combinatorial inputs to principle neurons of associative brain regions is established during development is unknown. Here, we explore the developmental patterning of sparse olfactory inputs to Kenyon cells of the Drosophila melanogaster mushroom body. By manipulating the ratio between pre- and post-synaptic cells, we find that postsynaptic Kenyon cells set convergence ratio: Kenyon cells produce fixed distributions of dendritic claws while presynaptic processes are plastic. Moreover, we show that sparse odor responses are preserved in mushroom bodies with reduced cellular repertoires, suggesting that developmental specification of convergence ratio allows functional robustness. |
format | Online Article Text |
id | pubmed-7028369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70283692020-02-20 Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body Elkahlah, Najia A Rogow, Jackson A Ahmed, Maria Clowney, E Josephine eLife Developmental Biology In order to represent complex stimuli, principle neurons of associative learning regions receive combinatorial sensory inputs. Density of combinatorial innervation is theorized to determine the number of distinct stimuli that can be represented and distinguished from one another, with sparse innervation thought to optimize the complexity of representations in networks of limited size. How the convergence of combinatorial inputs to principle neurons of associative brain regions is established during development is unknown. Here, we explore the developmental patterning of sparse olfactory inputs to Kenyon cells of the Drosophila melanogaster mushroom body. By manipulating the ratio between pre- and post-synaptic cells, we find that postsynaptic Kenyon cells set convergence ratio: Kenyon cells produce fixed distributions of dendritic claws while presynaptic processes are plastic. Moreover, we show that sparse odor responses are preserved in mushroom bodies with reduced cellular repertoires, suggesting that developmental specification of convergence ratio allows functional robustness. eLife Sciences Publications, Ltd 2020-01-08 /pmc/articles/PMC7028369/ /pubmed/31913123 http://dx.doi.org/10.7554/eLife.52278 Text en © 2020, Elkahlah et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Elkahlah, Najia A Rogow, Jackson A Ahmed, Maria Clowney, E Josephine Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title | Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title_full | Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title_fullStr | Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title_full_unstemmed | Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title_short | Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body |
title_sort | presynaptic developmental plasticity allows robust sparse wiring of the drosophila mushroom body |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028369/ https://www.ncbi.nlm.nih.gov/pubmed/31913123 http://dx.doi.org/10.7554/eLife.52278 |
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