Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis

A 70-year-old woman with rheumatoid arthritis undergoing methotrexate (MTX) treatment presented with dyspnea and a subfever. Computed tomography (CT) revealed a diffuse minimal ground-glass appearance in both lungs and splenomegaly. The gallium scintigram showed a diffuse, mild uptake in both lungs...

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Autores principales: Iwami, Eri, Ito, Fumimaro, Sasahara, Kotaro, Kuroda, Aoi, Matsuzaki, Tatsu, Nakajima, Takahiro, Abe, Daichi, Matsumoto, Kimihiro, Sasaki, Aya, Eguchi, Keisuke, Terashima, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028407/
https://www.ncbi.nlm.nih.gov/pubmed/31619597
http://dx.doi.org/10.2169/internalmedicine.3216-19
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author Iwami, Eri
Ito, Fumimaro
Sasahara, Kotaro
Kuroda, Aoi
Matsuzaki, Tatsu
Nakajima, Takahiro
Abe, Daichi
Matsumoto, Kimihiro
Sasaki, Aya
Eguchi, Keisuke
Terashima, Takeshi
author_facet Iwami, Eri
Ito, Fumimaro
Sasahara, Kotaro
Kuroda, Aoi
Matsuzaki, Tatsu
Nakajima, Takahiro
Abe, Daichi
Matsumoto, Kimihiro
Sasaki, Aya
Eguchi, Keisuke
Terashima, Takeshi
author_sort Iwami, Eri
collection PubMed
description A 70-year-old woman with rheumatoid arthritis undergoing methotrexate (MTX) treatment presented with dyspnea and a subfever. Computed tomography (CT) revealed a diffuse minimal ground-glass appearance in both lungs and splenomegaly. The gallium scintigram showed a diffuse, mild uptake in both lungs and the spleen. The lung biopsy specimen revealed the presence of CD20-positive atypical lymphocytes in the small pulmonary vessels. The patient was diagnosed with pulmonary intravascular diffuse large B-cell lymphoma (IVLBCL) and exhibited spontaneous regression after MTX was discontinued. This report describes a rare case of MTX-associated lymphoproliferative disorder expressing pulmonary IVLBCL.
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spelling pubmed-70284072020-02-26 Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis Iwami, Eri Ito, Fumimaro Sasahara, Kotaro Kuroda, Aoi Matsuzaki, Tatsu Nakajima, Takahiro Abe, Daichi Matsumoto, Kimihiro Sasaki, Aya Eguchi, Keisuke Terashima, Takeshi Intern Med Case Report A 70-year-old woman with rheumatoid arthritis undergoing methotrexate (MTX) treatment presented with dyspnea and a subfever. Computed tomography (CT) revealed a diffuse minimal ground-glass appearance in both lungs and splenomegaly. The gallium scintigram showed a diffuse, mild uptake in both lungs and the spleen. The lung biopsy specimen revealed the presence of CD20-positive atypical lymphocytes in the small pulmonary vessels. The patient was diagnosed with pulmonary intravascular diffuse large B-cell lymphoma (IVLBCL) and exhibited spontaneous regression after MTX was discontinued. This report describes a rare case of MTX-associated lymphoproliferative disorder expressing pulmonary IVLBCL. The Japanese Society of Internal Medicine 2019-10-17 2020-02-01 /pmc/articles/PMC7028407/ /pubmed/31619597 http://dx.doi.org/10.2169/internalmedicine.3216-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iwami, Eri
Ito, Fumimaro
Sasahara, Kotaro
Kuroda, Aoi
Matsuzaki, Tatsu
Nakajima, Takahiro
Abe, Daichi
Matsumoto, Kimihiro
Sasaki, Aya
Eguchi, Keisuke
Terashima, Takeshi
Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title_full Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title_fullStr Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title_full_unstemmed Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title_short Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis
title_sort pulmonary intravascular large b-cell lymphoma in a patient administered methotrexate for rheumatoid arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028407/
https://www.ncbi.nlm.nih.gov/pubmed/31619597
http://dx.doi.org/10.2169/internalmedicine.3216-19
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