An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy

We analyzed the ERG gene status using fluorescence in situ hybridization (FISH) in two chemotherapy-naïve cases with metastatic castration-resistant prostate cancer (mCRPC) in which abiraterone demonstrated a long-term durable complete response. FISH identified Class 1 Edel and Class 2+ Edel in case...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshizawa, Tsuyoshi, Yamaguchi, Kenya, Kawata, Nozomu, Ryuzaki, Hitomi, Ogawa, Masahiro, Obinata, Daisuke, Mochida, Junichi, Takahashi, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028414/
https://www.ncbi.nlm.nih.gov/pubmed/31619598
http://dx.doi.org/10.2169/internalmedicine.3302-19
_version_ 1783499011257270272
author Yoshizawa, Tsuyoshi
Yamaguchi, Kenya
Kawata, Nozomu
Ryuzaki, Hitomi
Ogawa, Masahiro
Obinata, Daisuke
Mochida, Junichi
Takahashi, Satoru
author_facet Yoshizawa, Tsuyoshi
Yamaguchi, Kenya
Kawata, Nozomu
Ryuzaki, Hitomi
Ogawa, Masahiro
Obinata, Daisuke
Mochida, Junichi
Takahashi, Satoru
author_sort Yoshizawa, Tsuyoshi
collection PubMed
description We analyzed the ERG gene status using fluorescence in situ hybridization (FISH) in two chemotherapy-naïve cases with metastatic castration-resistant prostate cancer (mCRPC) in which abiraterone demonstrated a long-term durable complete response. FISH identified Class 1 Edel and Class 2+ Edel in case 1, and Class 1 Edel in case 2. Our experience suggests that abiraterone may be effective in cases with mCRPC and ERG gene abnormalities, particularly Class 2+ Edel or Class 1 Edel. This is the first report of two cases with mCRPC that simultaneously investigated the ERG gene status and clinical aspects, including image evaluations and pathology.
format Online
Article
Text
id pubmed-7028414
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-70284142020-02-26 An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy Yoshizawa, Tsuyoshi Yamaguchi, Kenya Kawata, Nozomu Ryuzaki, Hitomi Ogawa, Masahiro Obinata, Daisuke Mochida, Junichi Takahashi, Satoru Intern Med Case Report We analyzed the ERG gene status using fluorescence in situ hybridization (FISH) in two chemotherapy-naïve cases with metastatic castration-resistant prostate cancer (mCRPC) in which abiraterone demonstrated a long-term durable complete response. FISH identified Class 1 Edel and Class 2+ Edel in case 1, and Class 1 Edel in case 2. Our experience suggests that abiraterone may be effective in cases with mCRPC and ERG gene abnormalities, particularly Class 2+ Edel or Class 1 Edel. This is the first report of two cases with mCRPC that simultaneously investigated the ERG gene status and clinical aspects, including image evaluations and pathology. The Japanese Society of Internal Medicine 2019-10-17 2020-02-01 /pmc/articles/PMC7028414/ /pubmed/31619598 http://dx.doi.org/10.2169/internalmedicine.3302-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yoshizawa, Tsuyoshi
Yamaguchi, Kenya
Kawata, Nozomu
Ryuzaki, Hitomi
Ogawa, Masahiro
Obinata, Daisuke
Mochida, Junichi
Takahashi, Satoru
An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title_full An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title_fullStr An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title_full_unstemmed An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title_short An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy
title_sort erg gene analysis in two cases with metastatic castration-resistant prostate cancer in which abiraterone demonstrated long-term efficacy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028414/
https://www.ncbi.nlm.nih.gov/pubmed/31619598
http://dx.doi.org/10.2169/internalmedicine.3302-19
work_keys_str_mv AT yoshizawatsuyoshi anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT yamaguchikenya anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT kawatanozomu anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT ryuzakihitomi anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT ogawamasahiro anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT obinatadaisuke anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT mochidajunichi anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT takahashisatoru anerggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT yoshizawatsuyoshi erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT yamaguchikenya erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT kawatanozomu erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT ryuzakihitomi erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT ogawamasahiro erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT obinatadaisuke erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT mochidajunichi erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy
AT takahashisatoru erggeneanalysisintwocaseswithmetastaticcastrationresistantprostatecancerinwhichabirateronedemonstratedlongtermefficacy

Ejemplares similares