Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma

We herein report the case of a 67-year-old man who presented with the acute onset of limb weakness. Brain magnetic resonance imaging revealed multiple abnormal-signal-intensity lesions. Steroids were administered, and the patient initially responded. Nerve conduction testing findings were consistent...

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Detalles Bibliográficos
Autores principales: Fukami, Yuki, Koike, Haruki, Iijima, Masahiro, Hagita, Junichirou, Niwa, Hisayoshi, Nishi, Ryoji, Kawagashira, Yuichi, Katsuno, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028418/
https://www.ncbi.nlm.nih.gov/pubmed/31588080
http://dx.doi.org/10.2169/internalmedicine.3228-19
Descripción
Sumario:We herein report the case of a 67-year-old man who presented with the acute onset of limb weakness. Brain magnetic resonance imaging revealed multiple abnormal-signal-intensity lesions. Steroids were administered, and the patient initially responded. Nerve conduction testing findings were consistent with demyelinating polyneuropathy. A sural nerve biopsy specimen revealed fascicles with extensive onion-bulb formation. Although skin and sural nerve biopsies showed no atypical cellular infiltration, the histopathological diagnosis of intravascular large B-cell lymphoma was obtained by a brain biopsy. The neuropathy in this patient may be attributed to a demyelinating process independent of ischemic damage by lymphoma.

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