Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1

BACKGROUND: The histone demethylase LSD1 is a key mediator driving tumorigenesis, which holds potential as a promising therapeutic target. However, treatment with LSD1 inhibitors alone failed to result in complete cancer regression. METHODS: The synergistic effects of TCP (a LSD1 inhibitor) and GSK-...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Cheng, Jie, Diao, Pengfei, Wang, Dongmiao, Jiang, Hongbing, Wang, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028736/
https://www.ncbi.nlm.nih.gov/pubmed/31848446
http://dx.doi.org/10.1038/s41416-019-0680-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028736/
https://www.ncbi.nlm.nih.gov/pubmed/31848446
http://dx.doi.org/10.1038/s41416-019-0680-6

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