Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice

Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two break points in the tricarboxylic acid cycle of M1 macrophages, and aspartate‐arginosuccinate shunt compensates them. Aminoox...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Pei, Zhou, Wenjing, Zhang, Yanxia, Li, Jingjing, Zhao, Ye, Pan, Lihua, Shen, Zhenya, Chen, Weiqian, Hui, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028849/
https://www.ncbi.nlm.nih.gov/pubmed/31930778
http://dx.doi.org/10.1111/jcmm.14972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028849/
https://www.ncbi.nlm.nih.gov/pubmed/31930778
http://dx.doi.org/10.1111/jcmm.14972

Ejemplares similares