CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high‐fat diet‐induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway

CTRP9 has been reported to regulate lipid metabolism and exert cardioprotective effects, yet its role in high‐fat diet (HFD)‐induced cardiac lipotoxicity and the underlying mechanisms remain unclear. In the current study, we established HFD‐induced obesity model in wild‐type (WT) or CTRP9 knockout (...

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Detalles Bibliográficos
Autores principales: Zuo, Anju, Zhao, Xiaoyu, Li, Tingting, Li, Jun, Lei, Shengyun, Chen, Jiying, Xu, Dan, Song, Chengxiang, Liu, Tianjiao, Li, Cuigang, Guo, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028852/
https://www.ncbi.nlm.nih.gov/pubmed/31930700
http://dx.doi.org/10.1111/jcmm.14982

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