Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling

The endoplasmic reticulum (ER)-stress-induced cascade events are implicated in Parkinson’s disease (PD). The discovery of drug candidates to protect dopaminergic (DA) neurons from ER-stress-induced oxidative damage is important to resolve the pathological aspects of PD and modify its progress. In th...

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Detalles Bibliográficos
Autores principales: Ke, Minjing, Chong, Cheong-Meng, Zeng, Haitao, Huang, Miaodan, Huang, Zhijian, Zhang, Ke, Cen, Xiaotong, Lu, Jia-Hong, Yao, Xiaoli, Qin, Dajiang, Su, Huanxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028918/
https://www.ncbi.nlm.nih.gov/pubmed/32071291
http://dx.doi.org/10.1038/s41419-020-2312-8

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