Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration (IVDD). NLR pyrin domain containing 3 (NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflam...

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Detalles Bibliográficos
Autores principales: Chen, Fan, Jiang, Guowei, Liu, Hui, Li, Zemin, Pei, Yuxin, Wang, Hua, Pan, Hehai, Cui, Haowen, Long, Jun, Wang, Jianru, Zheng, Zhaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028926/
https://www.ncbi.nlm.nih.gov/pubmed/32133213
http://dx.doi.org/10.1038/s41413-020-0087-2

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