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Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

The molecular events causing memory loss and neuronal cell death in Alzheimer’s disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with BV2 cells or rat astrocytes caused a sensitised respon...

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Detalles Bibliográficos
Autores principales:	Hughes, Craig, Choi, Minee L., Yi, Jee-Hyun, Kim, Seung-Chan, Drews, Anna, George-Hyslop, Peter St., Bryant, Clare, Gandhi, Sonia, Cho, Kwangwook, Klenerman, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028984/ https://www.ncbi.nlm.nih.gov/pubmed/32071389 http://dx.doi.org/10.1038/s42003-020-0792-9

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