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PLAGL2 promotes epithelial–mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1

BACKGROUND: We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in the pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed in several malignant tumours. However, the exact function of PLAGL2 and its underlying mechanism in colorectal can...

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Detalles Bibliográficos
Autores principales:	Wu, Liang, Zhou, Zili, Han, Shengbo, Chen, Jinhuang, Liu, Zhengyi, Zhang, Xudan, Yuan, Wenzheng, Ji, Jintong, Shu, Xiaogang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028997/ https://www.ncbi.nlm.nih.gov/pubmed/31827238 http://dx.doi.org/10.1038/s41416-019-0679-z

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