Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Oxidative stress is a major pathogenic mechanism in Parkinson’s disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage. GSH level is decreased in the brains of PD patients. Hence, clari...

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Detalles Bibliográficos
Autores principales: Wei, Yao, Lu, Ming, Mei, Meng, Wang, Haoran, Han, Zhitao, Chen, Miaomiao, Yao, Hang, Song, Nanshan, Ding, Xiao, Ding, Jianhua, Xiao, Ming, Hu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029000/
https://www.ncbi.nlm.nih.gov/pubmed/32071304
http://dx.doi.org/10.1038/s41467-020-14788-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029000/
https://www.ncbi.nlm.nih.gov/pubmed/32071304
http://dx.doi.org/10.1038/s41467-020-14788-x

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