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First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in ex vivo mouse heart

The hexosamine biosynthesis pathway (HBP) branches from glycolysis and forms UDP-GlcNAc, the moiety for O-linked β-GlcNAc (O-GlcNAc) post-translational modifications. An inability to directly measure HBP flux has hindered our understanding of the factors regulating protein O-GlcNAcylation. Our goals...

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Detalles Bibliográficos
Autores principales:	Olson, Aaron K., Bouchard, Bertrand, Zhu, Wei Zhong, Chatham, John C., Des Rosiers, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029105/ https://www.ncbi.nlm.nih.gov/pubmed/31915250 http://dx.doi.org/10.1074/jbc.RA119.010565

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