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Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatment...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Speaking Orthopaedic Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029343/ https://www.ncbi.nlm.nih.gov/pubmed/32099807 http://dx.doi.org/10.1016/j.jot.2019.10.012 |
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author | Wu, Xiaoxin Wang, Yuewen Xiao, Yin Crawford, Ross Mao, Xinzhan Prasadam, Indira |
author_facet | Wu, Xiaoxin Wang, Yuewen Xiao, Yin Crawford, Ross Mao, Xinzhan Prasadam, Indira |
author_sort | Wu, Xiaoxin |
collection | PubMed |
description | Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatments simply aim to reduce pain and swelling. Exosomes are membrane-bound extracellular vesicles secreted by almost all cells, receiving increasing interest because of their effect in cell-to-cell communication. Increasing evidence suggests that exosomes play an important role in cartilage physiological and pathological effects. This article reviews the potential role of exosomes in OA regenerative medicine. Special attention is given to mesenchymal stem cells-derived exosomes due to the extensive research on their cartilage repair property and their function as miRNA cargo. More investigations are needed for the effects of exosomes from synovial fluid and chondrocytes in joints. A better understanding of the mechanisms will contribute to a novel and promising therapy for OA patients. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: A better understanding of the role of extracellular vesicles in regenerative medicine will contribute to a novel and promising therapy for OA patients. |
format | Online Article Text |
id | pubmed-7029343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Chinese Speaking Orthopaedic Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-70293432020-02-25 Extracellular vesicles: Potential role in osteoarthritis regenerative medicine Wu, Xiaoxin Wang, Yuewen Xiao, Yin Crawford, Ross Mao, Xinzhan Prasadam, Indira J Orthop Translat Review Article Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatments simply aim to reduce pain and swelling. Exosomes are membrane-bound extracellular vesicles secreted by almost all cells, receiving increasing interest because of their effect in cell-to-cell communication. Increasing evidence suggests that exosomes play an important role in cartilage physiological and pathological effects. This article reviews the potential role of exosomes in OA regenerative medicine. Special attention is given to mesenchymal stem cells-derived exosomes due to the extensive research on their cartilage repair property and their function as miRNA cargo. More investigations are needed for the effects of exosomes from synovial fluid and chondrocytes in joints. A better understanding of the mechanisms will contribute to a novel and promising therapy for OA patients. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: A better understanding of the role of extracellular vesicles in regenerative medicine will contribute to a novel and promising therapy for OA patients. Chinese Speaking Orthopaedic Society 2019-12-06 /pmc/articles/PMC7029343/ /pubmed/32099807 http://dx.doi.org/10.1016/j.jot.2019.10.012 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Wu, Xiaoxin Wang, Yuewen Xiao, Yin Crawford, Ross Mao, Xinzhan Prasadam, Indira Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title | Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title_full | Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title_fullStr | Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title_full_unstemmed | Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title_short | Extracellular vesicles: Potential role in osteoarthritis regenerative medicine |
title_sort | extracellular vesicles: potential role in osteoarthritis regenerative medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029343/ https://www.ncbi.nlm.nih.gov/pubmed/32099807 http://dx.doi.org/10.1016/j.jot.2019.10.012 |
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