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Extracellular vesicles: Potential role in osteoarthritis regenerative medicine

Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatment...

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Detalles Bibliográficos
Autores principales: Wu, Xiaoxin, Wang, Yuewen, Xiao, Yin, Crawford, Ross, Mao, Xinzhan, Prasadam, Indira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029343/
https://www.ncbi.nlm.nih.gov/pubmed/32099807
http://dx.doi.org/10.1016/j.jot.2019.10.012
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author Wu, Xiaoxin
Wang, Yuewen
Xiao, Yin
Crawford, Ross
Mao, Xinzhan
Prasadam, Indira
author_facet Wu, Xiaoxin
Wang, Yuewen
Xiao, Yin
Crawford, Ross
Mao, Xinzhan
Prasadam, Indira
author_sort Wu, Xiaoxin
collection PubMed
description Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatments simply aim to reduce pain and swelling. Exosomes are membrane-bound extracellular vesicles secreted by almost all cells, receiving increasing interest because of their effect in cell-to-cell communication. Increasing evidence suggests that exosomes play an important role in cartilage physiological and pathological effects. This article reviews the potential role of exosomes in OA regenerative medicine. Special attention is given to mesenchymal stem cells-derived exosomes due to the extensive research on their cartilage repair property and their function as miRNA cargo. More investigations are needed for the effects of exosomes from synovial fluid and chondrocytes in joints. A better understanding of the mechanisms will contribute to a novel and promising therapy for OA patients. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: A better understanding of the role of extracellular vesicles in regenerative medicine will contribute to a novel and promising therapy for OA patients.
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spelling pubmed-70293432020-02-25 Extracellular vesicles: Potential role in osteoarthritis regenerative medicine Wu, Xiaoxin Wang, Yuewen Xiao, Yin Crawford, Ross Mao, Xinzhan Prasadam, Indira J Orthop Translat Review Article Osteoarthritis (OA) is a prevalent whole joint disease characterised by cartilage degradation, subchondral bone sclerosis and bone remodelling, and synovium inflammation, leading to pain, deformity, and cartilage dysfunction. Currently, there is no appropriate therapy for OA, and available treatments simply aim to reduce pain and swelling. Exosomes are membrane-bound extracellular vesicles secreted by almost all cells, receiving increasing interest because of their effect in cell-to-cell communication. Increasing evidence suggests that exosomes play an important role in cartilage physiological and pathological effects. This article reviews the potential role of exosomes in OA regenerative medicine. Special attention is given to mesenchymal stem cells-derived exosomes due to the extensive research on their cartilage repair property and their function as miRNA cargo. More investigations are needed for the effects of exosomes from synovial fluid and chondrocytes in joints. A better understanding of the mechanisms will contribute to a novel and promising therapy for OA patients. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: A better understanding of the role of extracellular vesicles in regenerative medicine will contribute to a novel and promising therapy for OA patients. Chinese Speaking Orthopaedic Society 2019-12-06 /pmc/articles/PMC7029343/ /pubmed/32099807 http://dx.doi.org/10.1016/j.jot.2019.10.012 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wu, Xiaoxin
Wang, Yuewen
Xiao, Yin
Crawford, Ross
Mao, Xinzhan
Prasadam, Indira
Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title_full Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title_fullStr Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title_full_unstemmed Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title_short Extracellular vesicles: Potential role in osteoarthritis regenerative medicine
title_sort extracellular vesicles: potential role in osteoarthritis regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029343/
https://www.ncbi.nlm.nih.gov/pubmed/32099807
http://dx.doi.org/10.1016/j.jot.2019.10.012
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