Family History is Associated with Phenotype in Dementia with Lewy Bodies

It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson’s disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Vergouw, Leonie J.M., Bosman, Brechje, van de Beek, Marleen, Salomé, Mariet, Hoogers, Susanne E., van Steenoven, Inger, Roks, Gerwin, Bonifati, Vincenzo, van Swieten, John C., Lemstra, Afina W., de Jong, Frank Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029358/
https://www.ncbi.nlm.nih.gov/pubmed/31771063
http://dx.doi.org/10.3233/JAD-190825
_version_ 1783499152670326784
author Vergouw, Leonie J.M.
Bosman, Brechje
van de Beek, Marleen
Salomé, Mariet
Hoogers, Susanne E.
van Steenoven, Inger
Roks, Gerwin
Bonifati, Vincenzo
van Swieten, John C.
Lemstra, Afina W.
de Jong, Frank Jan
author_facet Vergouw, Leonie J.M.
Bosman, Brechje
van de Beek, Marleen
Salomé, Mariet
Hoogers, Susanne E.
van Steenoven, Inger
Roks, Gerwin
Bonifati, Vincenzo
van Swieten, John C.
Lemstra, Afina W.
de Jong, Frank Jan
author_sort Vergouw, Leonie J.M.
collection PubMed
description It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson’s disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and Alzheimer’s disease (AD) biomarkers in patients with familial DLB (n = 154) and sporadic DLB (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p≤0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis.
format Online
Article
Text
id pubmed-7029358
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-70293582020-03-04 Family History is Associated with Phenotype in Dementia with Lewy Bodies Vergouw, Leonie J.M. Bosman, Brechje van de Beek, Marleen Salomé, Mariet Hoogers, Susanne E. van Steenoven, Inger Roks, Gerwin Bonifati, Vincenzo van Swieten, John C. Lemstra, Afina W. de Jong, Frank Jan J Alzheimers Dis Research Article It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson’s disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and Alzheimer’s disease (AD) biomarkers in patients with familial DLB (n = 154) and sporadic DLB (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p≤0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis. IOS Press 2020-01-07 /pmc/articles/PMC7029358/ /pubmed/31771063 http://dx.doi.org/10.3233/JAD-190825 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vergouw, Leonie J.M.
Bosman, Brechje
van de Beek, Marleen
Salomé, Mariet
Hoogers, Susanne E.
van Steenoven, Inger
Roks, Gerwin
Bonifati, Vincenzo
van Swieten, John C.
Lemstra, Afina W.
de Jong, Frank Jan
Family History is Associated with Phenotype in Dementia with Lewy Bodies
title Family History is Associated with Phenotype in Dementia with Lewy Bodies
title_full Family History is Associated with Phenotype in Dementia with Lewy Bodies
title_fullStr Family History is Associated with Phenotype in Dementia with Lewy Bodies
title_full_unstemmed Family History is Associated with Phenotype in Dementia with Lewy Bodies
title_short Family History is Associated with Phenotype in Dementia with Lewy Bodies
title_sort family history is associated with phenotype in dementia with lewy bodies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029358/
https://www.ncbi.nlm.nih.gov/pubmed/31771063
http://dx.doi.org/10.3233/JAD-190825
work_keys_str_mv AT vergouwleoniejm familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT bosmanbrechje familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT vandebeekmarleen familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT salomemariet familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT hoogerssusannee familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT vansteenoveninger familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT roksgerwin familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT bonifativincenzo familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT vanswietenjohnc familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT lemstraafinaw familyhistoryisassociatedwithphenotypeindementiawithlewybodies
AT dejongfrankjan familyhistoryisassociatedwithphenotypeindementiawithlewybodies

Ejemplares similares