A novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration

BACKGROUND: Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration,...

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Detalles Bibliográficos
Autores principales: Zhao, Zhan, Wang, Yubao, Zhou, Ran, Li, Yi, Gao, Yun, Tu, Dezhen, Wilson, Belinda, Song, Sheng, Feng, Jing, Hong, Jau-Shyong, Yakel, Jerrel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029475/
https://www.ncbi.nlm.nih.gov/pubmed/32070376
http://dx.doi.org/10.1186/s12974-020-1728-5

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