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A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG

BACKGROUND: NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a conserved pluripotency-associated factor. However, pig NANOG reporter PSCs have...

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Detalles Bibliográficos
Autores principales:	Xu, Junjun, Zheng, Zheng, Du, Xuguang, Shi, Bingbo, Wang, Jichang, Gao, Dengfeng, Zhu, Qianqian, Chen, Xinze, Han, Jianyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029561/ https://www.ncbi.nlm.nih.gov/pubmed/32070424 http://dx.doi.org/10.1186/s13287-020-1588-z

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