Cargando…

Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disorder strongly correlated with a dysfunctional immune system. Our previous results demonstrated that inactivated influenza vaccine (IIV) facilitates hippocampal neurogenesis and blocks lipopolysaccharide (LPS)-induced cognitive impairmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yunjie, He, Zitian, Xing, Zhiwei, Zuo, Zejie, Yuan, Lifang, Wu, Yingying, Jiang, Mei, Qi, Fangfang, Yao, Zhibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029575/ https://www.ncbi.nlm.nih.gov/pubmed/32075657 http://dx.doi.org/10.1186/s12974-020-01741-4

Ejemplares similares

Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice
por: He, Zitian, et al.
Publicado: (2020)

Prenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
por: Wu, Yingying, et al.
Publicado: (2018)

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
por: Zhang, Jian-Xiang, et al.
Publicado: (2019)

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
por: Yang, Wenjuan, et al.
Publicado: (2018)

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
por: Kim, Hye Yun, et al.
Publicado: (2015)

Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
por: Wang, Xiao-feng, et al.
Publicado: (2021)

Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice
por: Gureviciene, Irina, et al.
Publicado: (2019)

Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice
por: Shi, Jing, et al.
Publicado: (2023)

Corrigendum: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
por: Kim, Hye Yun, et al.
Publicado: (2016)

Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice
por: Wang, Zigao, et al.
Publicado: (2017)

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis
por: Lin, Kaili, et al.
Publicado: (2021)

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss
por: Zhou, Wei, et al.
Publicado: (2019)

Effects of collagen-induced rheumatoid arthritis on amyloidosis and microvascular pathology in APP/PS1 mice
por: Park, Sun Mi, et al.
Publicado: (2011)

Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
por: Zhang, Zhi-Yuan, et al.
Publicado: (2013)

Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis
por: Mifflin, Marc A., et al.
Publicado: (2021)

Bis(9)-(−)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
por: Shi, Yuhuan, et al.
Publicado: (2018)

Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice
por: Jiang, Rong, et al.
Publicado: (2020)

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
por: Killick, Richard, et al.
Publicado: (2009)

Long-term icariin treatment ameliorates cognitive deficits via CD4(+) T cell-mediated immuno-inflammatory responses in APP/PS1 mice
por: Zhu, Tianrui, et al.
Publicado: (2019)

Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice
por: Su, Qiang, et al.
Publicado: (2021)

Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice
por: Li, Zongyang, et al.
Publicado: (2022)

Magnetization transfer contrast imaging detects early white matter changes in the APP/PS1 amyloidosis mouse model
por: Praet, Jelle, et al.
Publicado: (2016)

(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75(NTR) Signaling in APP/PS1 Transgenic Mice
por: Liu, Mingyan, et al.
Publicado: (2013)

Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction
por: Yang, Cuicui, et al.
Publicado: (2020)

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease
por: Sha, Sha, et al.
Publicado: (2022)

Human Neural Stem Cell Transplantation Rescues Cognitive Defects in APP/PS1 Model of Alzheimer’s Disease by Enhancing Neuronal Connectivity and Metabolic Activity
por: Li, Xueyuan, et al.
Publicado: (2016)

Deficit in hippocampal ripples does not preclude spatial memory formation in APP/PS1 mice
por: Jura, Bartosz, et al.
Publicado: (2019)

Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice
por: Luo, Biao, et al.
Publicado: (2023)

Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
por: Yu, Haizhen, et al.
Publicado: (2021)

Combined effect of BCG vaccination and enriched environment promote neurogenesis and spatial cognition via a shift in meningeal macrophage M2 polarization
por: Qi, Fangfang, et al.
Publicado: (2017)

MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice
por: Wu, Qingbin, et al.
Publicado: (2019)

Milrinone Ameliorates the Neuroinflammation and Memory Function of Alzheimer’s Disease in an APP/PS1 Mouse Model
por: Chen, Qingyou, et al.
Publicado: (2021)

Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APP(Sw,Ind) Transgenic Mice
por: Valero, Jorge, et al.
Publicado: (2011)

Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice
por: Wang, Sheng, et al.
Publicado: (2019)

Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
por: Fernandez-Valenzuela, Juan Jose, et al.
Publicado: (2020)

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis
por: Zhang, Zhi-Yuan, et al.
Publicado: (2014)

Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice
por: Lin, Ruhui, et al.
Publicado: (2018)

Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction
por: Xu, Yi-Jun, et al.
Publicado: (2018)

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
por: Li, Lei, et al.
Publicado: (2020)

Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer’s disease
por: Yu, WenJun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_e0jr8ha01019ur6vtd6dhcnorn