Single-nucleus RNA-seq identifies Huntington disease astrocyte states

Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to uncover cellular phenotypes that change in the disease, investigating single cell gene expression in cingulate cortex of patients with HD...

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Detalles Bibliográficos
Autores principales: Al-Dalahmah, Osama, Sosunov, Alexander A., Shaik, A., Ofori, Kenneth, Liu, Yang, Vonsattel, Jean Paul, Adorjan, Istvan, Menon, Vilas, Goldman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029580/
https://www.ncbi.nlm.nih.gov/pubmed/32070434
http://dx.doi.org/10.1186/s40478-020-0880-6

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