Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

Both circular RNAs (circRNAs) and cancer stem cells (CSCs) are separately known to be involved in cancer, but their interaction remains unclear. Here, the regulation of hepatocellular CSC self‐renewal is discovered by a circRNA, circ‐MALAT1, which is produced by back‐splicing of a long noncoding RNA...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Kong, Ruijiao, Wu, Cong, Wang, Shuo, Liu, Zixin, Liu, Shupeng, Li, Shuiping, Chen, Tian, Mao, Chuanbin, Liu, Shanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029649/
https://www.ncbi.nlm.nih.gov/pubmed/32099751
http://dx.doi.org/10.1002/advs.201900949

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