Cell Delivery: Routing Nanomolar Protein Cargoes to Lipid Raft‐Mediated/Caveolar Endocytosis through a Ganglioside GM1‐Specific Recognition Tag (Adv. Sci. 4/2020)

In article number https://doi.org/10.1002/advs.201902621, Tamás A. Martinek and co‐workers develop a pentapeptidic tag, which reads the glycan code of ganglioside GM1 and triggers lipid raft‐mediated endocytosis, avoiding lysosomal entrapment. This carrier molecule can deliver macromolecular cargoes...

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Detalles Bibliográficos
Autores principales: Imre, Norbert, Hetényi, Anasztázia, Szabó, Enikő, Bodnár, Brigitta, Szkalisity, Abel, Gróf, Ilona, Bocsik, Alexandra, Deli, Mária A., Horvath, Peter, Czibula, Ágnes, Monostori, Éva, Martinek, Tamás A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029659/
http://dx.doi.org/10.1002/advs.202070019
Descripción
Sumario:In article number https://doi.org/10.1002/advs.201902621, Tamás A. Martinek and co‐workers develop a pentapeptidic tag, which reads the glycan code of ganglioside GM1 and triggers lipid raft‐mediated endocytosis, avoiding lysosomal entrapment. This carrier molecule can deliver macromolecular cargoes (e.g., IgG complexes) into live cells with the possibility to escape to the cytosol. [Image: see text]

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