Cargando…
Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan
With a rising aging population, it is important to develop behavioral tasks that assess and track cognitive decline, and to identify protective factors that promote healthy brain aging. Mnemonic discrimination tasks that rely on pattern separation mechanisms are a promising metric to detect subtle a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029721/ https://www.ncbi.nlm.nih.gov/pubmed/32071255 http://dx.doi.org/10.1101/lm.049197.118 |
_version_ | 1783499225801162752 |
---|---|
author | Nauer, Rachel K. Schon, Karin Stern, Chantal E. |
author_facet | Nauer, Rachel K. Schon, Karin Stern, Chantal E. |
author_sort | Nauer, Rachel K. |
collection | PubMed |
description | With a rising aging population, it is important to develop behavioral tasks that assess and track cognitive decline, and to identify protective factors that promote healthy brain aging. Mnemonic discrimination tasks that rely on pattern separation mechanisms are a promising metric to detect subtle age-related memory impairments. Behavioral performance on these tasks rely on the integrity of the hippocampus and surrounding circuitry, which are brain regions known to be adversely affected in aging and neurodegenerative disorders. Aerobic exercise, which improves cardiorespiratory fitness (CRF), has been shown to counteract aging-related decreases in structural and functional brain integrity and attenuate decline of cognitive performance. Here, we tested the hypothesis that higher CRF attenuates age-related deficits in mnemonic discrimination in both a nonspatial mnemonic discrimination (Mnemonic Similarity Task) and a virtual navigation task (Route Disambiguation Task). Importantly, we included individuals across the lifespan (aged 18–83 yr), including the middle-age range, to determine mnemonic discrimination performance across adulthood. Participants completed two mnemonic discrimination tasks and a treadmill test to assess CRF. Our results demonstrate robust negative age-related effects on mnemonic discrimination performance across both the nonspatial and spatial domains. Critically, higher CRF mitigated age-related attenuation in spatial contextual discrimination task performance, but did not show an attenuation effect on performance for object-based mnemonic discrimination. These results suggest that performance on spatial mnemonic discrimination may be a useful tool to track vulnerability in older individuals at risk for cognitive decline, and that higher CRF may lead to cognitive preservation across the adult lifespan, particularly for spatial disambiguation of similar contexts. |
format | Online Article Text |
id | pubmed-7029721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70297212021-03-01 Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan Nauer, Rachel K. Schon, Karin Stern, Chantal E. Learn Mem Research With a rising aging population, it is important to develop behavioral tasks that assess and track cognitive decline, and to identify protective factors that promote healthy brain aging. Mnemonic discrimination tasks that rely on pattern separation mechanisms are a promising metric to detect subtle age-related memory impairments. Behavioral performance on these tasks rely on the integrity of the hippocampus and surrounding circuitry, which are brain regions known to be adversely affected in aging and neurodegenerative disorders. Aerobic exercise, which improves cardiorespiratory fitness (CRF), has been shown to counteract aging-related decreases in structural and functional brain integrity and attenuate decline of cognitive performance. Here, we tested the hypothesis that higher CRF attenuates age-related deficits in mnemonic discrimination in both a nonspatial mnemonic discrimination (Mnemonic Similarity Task) and a virtual navigation task (Route Disambiguation Task). Importantly, we included individuals across the lifespan (aged 18–83 yr), including the middle-age range, to determine mnemonic discrimination performance across adulthood. Participants completed two mnemonic discrimination tasks and a treadmill test to assess CRF. Our results demonstrate robust negative age-related effects on mnemonic discrimination performance across both the nonspatial and spatial domains. Critically, higher CRF mitigated age-related attenuation in spatial contextual discrimination task performance, but did not show an attenuation effect on performance for object-based mnemonic discrimination. These results suggest that performance on spatial mnemonic discrimination may be a useful tool to track vulnerability in older individuals at risk for cognitive decline, and that higher CRF may lead to cognitive preservation across the adult lifespan, particularly for spatial disambiguation of similar contexts. Cold Spring Harbor Laboratory Press 2020-03 /pmc/articles/PMC7029721/ /pubmed/32071255 http://dx.doi.org/10.1101/lm.049197.118 Text en © 2020 Nauer et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Nauer, Rachel K. Schon, Karin Stern, Chantal E. Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title | Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title_full | Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title_fullStr | Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title_full_unstemmed | Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title_short | Cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
title_sort | cardiorespiratory fitness and mnemonic discrimination across the adult lifespan |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029721/ https://www.ncbi.nlm.nih.gov/pubmed/32071255 http://dx.doi.org/10.1101/lm.049197.118 |
work_keys_str_mv | AT nauerrachelk cardiorespiratoryfitnessandmnemonicdiscriminationacrosstheadultlifespan AT schonkarin cardiorespiratoryfitnessandmnemonicdiscriminationacrosstheadultlifespan AT sternchantale cardiorespiratoryfitnessandmnemonicdiscriminationacrosstheadultlifespan |