Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study

(E)-N,N-dimethyl-4-oxo-4-(4-(pyridin-4-yl)phenyl)but-2-enamide hydrochloride (IMB-YH-4py5-2H) is a novel Protein Kinase B (PknB) inhibitor with potent activity against Mycobacterium tuberculosis strains. In the present study, a sensitive and specific liquid chromatography/tandem mass spectrometry (L...

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Detalles Bibliográficos
Autores principales: He, Sen, Chen, Hong-Tong, Zhao, Rui, Hu, Xin-Xin, Nie, Tong-Ying, Yang, Xin-Yi, Li, Cong-Ran, Lu, Xi, Wang, Xiu-Kun, Li, Xue, Lu, Yun, Li, Guo-Qing, Pang, Jing, You, Xue-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029871/
https://www.ncbi.nlm.nih.gov/pubmed/32074133
http://dx.doi.org/10.1371/journal.pone.0228797

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