Cargando…

3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening

Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones, desi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lobe, Maloba M. M., Efange, Simon M. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029914/ https://www.ncbi.nlm.nih.gov/pubmed/32218955 http://dx.doi.org/10.1098/rsos.191316

Ejemplares similares

Spiro[1,3-dioxolane-2,3′-indolin]-2′-one
por: Meng, Yan, et al.
Publicado: (2010)

Spiro[cyclopropane-1,3′-indolin]-2′-one
por: Yuan, Maosen, et al.
Publicado: (2011)

5-Chlorobenzothiazole-2-spiro-3′-indolin-2′-one
por: Akkurt, Mehmet, et al.
Publicado: (2010)

Tri(n-butyl)phosphine-promoted domino reaction for the efficient construction of spiro[cyclohexane-1,3'-indolines] and spiro[indoline-3,2'-furan-3',3''-indolines]
por: Zheng, Hui, et al.
Publicado: (2022)

Synthesis of functionalized spiro[indoline-3,4’-pyridines] and spiro[indoline-3,4’-pyridinones] via one-pot four-component reactions
por: Zhang, Li-Juan, et al.
Publicado: (2013)

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3′,4′-dihydro-1′H-spiro[isoindoline-2,2′-isoquinoline] skeleton
por: Bielawski, Krzysztof, et al.
Publicado: (2017)

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction
por: Fu, Qin, et al.
Publicado: (2013)

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives
por: Wang, Juxian, et al.
Publicado: (2012)

1′-Methyl-2,2′′-dioxoindoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-indoline-4′,4′-dicarbonitrile
por: Ramesh, P., et al.
Publicado: (2009)

Spirofused tetrahydroisoquinoline-oxindole hybrids as a novel class of fast acting antimalarial agents with multiple modes of action
por: Efange, Noella M., et al.
Publicado: (2020)

Spiro[indene-1,1′-benzo[e]indolin]-2′-one
por: Chen, Jin-Xiang, et al.
Publicado: (2010)

Methyl (3S,10b’S)-5-chloro-9′-fluoro-1-methyl-2-oxo-5′-phenyl-10b’H-spiro[indoline-3,1′-pyrazolo[3,2-a]isoquinoline]-2′-carboxylate
por: Kannan, Piskala Subburaman, et al.
Publicado: (2013)

10′-Chloro-3′,4′-dihydro-2′H-spiro[cyclopropane-1,7′(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one
por: Okuda, Kensuke, et al.
Publicado: (2012)

Synthesis of spiro[indoline-3,1[Formula: see text] -quinolizines] and spiro[indoline-3,4[Formula: see text] -pyrido[1,2-a]quinolines] via three-component reactions of azaarenes, acetylenedicarboxylate, and 3-methyleneoxindoles
por: Sun, Jing, et al.
Publicado: (2013)

5′-Amino-2-oxo-2′,3′-dihydrospiro[indoline-3,7′-thieno[3,2-b]pyran]-6′-carbonitrile 1′,1′-dioxide
por: Shen, Shi-De, et al.
Publicado: (2010)

(1S,3R)-3-Isobutyl-2,3-dihydrospiro[benzo[f]isoindole-1,3′-indoline]-2′,4,9-trione methanol monosolvate
por: Sharma, Garima, et al.
Publicado: (2012)

1′-Phenyl-6′-thiacycloheptane-1-spiro-2′-perhydropyrrolizine-3′-spiro-3′′-indoline-2,2′′-dione
por: Sundaramoorthy, S., et al.
Publicado: (2008)

5′-Chlorospiro[1,3-dioxolane-2,3′-indolin]-2′-one: a potential anticonvulsant
por: De, Amitabha
Publicado: (2008)

Crystal structure and Hirshfeld surface analysis of 4′-(2-chlorophenyl)-1′-methyl-3′′-phenyl-7′′,8′′-dihydro-5′′H-dispiro[indoline-3,2′-pyrrolidine-3′,6′′-isoquinoline]-2,5′′-dione
por: Vishnupriya, R., et al.
Publicado: (2018)

1-Benzyl-4′,5′-diphenylpiperidine-3-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-4,2′′-dione
por: Suresh, J., et al.
Publicado: (2008)

Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties
por: Fawazy, Nehmedo G., et al.
Publicado: (2022)

Crystal structure determination as part of an undergraduate laboratory experiment: 1′,3′,3′-trimethylspiro[chromene-2,2′-indoline] and 1′,3′,3′-trimethyl-4-[(E)-(1,3,3-trimethylindolin-2-ylidene)methyl]spiro[chroman-2,2′-indoline]
por: Beckett, Joseph O. S., et al.
Publicado: (2016)

Methyl 5′′-chloro-1′,1′′-dimethyl-2,2′′-dioxodispiro[indoline-3,2′-pyrrolidine-3′,3′′-indoline]-4′-carboxylate
por: Kannan, Piskala Subburaman, et al.
Publicado: (2013)

5-Amino-6-benzoyl-8-nitro-2,3-dihydro-1H-spiro[imidazo[1,2-a]pyridine-7,3′-indolin]-2′-one dimethyl sulfoxide monosolvate
por: Nagalakshmi, R. A., et al.
Publicado: (2014)

1′-Benzyl-4,4′′-bis(4-chlorophenyl)-3-(2,6-dichlorophenyl)-1′′-methyl-4,5-dihydroisoxazole-5-spiro-3′-piperidine-5′-spiro-3′′-pyrrolidine-2′′-spiro-3′′′-indoline-2′′′,4′-dione
por: Hou, Yongjiang
Publicado: (2009)

2-Hydroxy-3,3-dimethyl-7-nitro-3,4-dihydroisoquinolin-1(2H)-one
por: Ben Salah, Hassen, et al.
Publicado: (2008)

5,6-Dimethoxy-4′,5′-diphenylindane-2-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-1,2′′-dione
por: Ali, Mohamed Ashraf, et al.
Publicado: (2010)

Crystal structure and Hirshfeld surface analysis of methyl 4′-amino-3′,5′-dicyano-2,2′′-dioxodispiro[indoline-3,1′-cyclopentane-2′,3′′-indolin]-3′-ene-5′-carboximidate with an unknown solvent
por: Naghiyev, Farid N., et al.
Publicado: (2022)

4′-(2,4-Dichlorophenyl)-1,1′-dimethylpiperidine-3-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-4,2′′-dione
por: Nagamuthu, S., et al.
Publicado: (2010)

Crystal structure of methyl 1-methyl-2-oxospiro[indoline-3,2′-oxirane]-3′-carboxylate
por: Savithri, M. P., et al.
Publicado: (2015)

1′′-Benzyl-1′-methyl-4′-(naphthalen-1-yl)naphthalene-2-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-1,2′′-dione
por: Selvanayagam, S., et al.
Publicado: (2011)

3′-Hydroxymethyl-1′-methyl-3′-nitro-4′-(o-tolyl)spiro[indoline-3,2′-pyrrolidin]-2-one
por: Gangadharan, Rajeswari, et al.
Publicado: (2010)

Correction: Rhodium-catalyzed cycloaddition of carbonyl ylides for the synthesis of spiro[furo[2,3-a]xanthene-2,3′-indolin]-2′-one scaffolds
por: Subba Reddy, B. V., et al.
Publicado: (2018)

5′,6-Dichloro-1′,3′,3′-trimethylspiro[2H-1-benzopyran-2,2′-indoline]
por: Alhashimy, Nameer, et al.
Publicado: (2008)

Crystal structure of (1′S,2′S,3S)-1′-benzoyl-2′-(4-methoxyphenyl)-1-methyl-2′,5′,6′,10b′-tetrahydro-1′H-spiro[indoline-3,3′-pyrrolo[2,1-a]isoquinolin]-2-one
por: Selvaraj, Janet Priyavathani, et al.
Publicado: (2020)

(1′S)-4-(3,4-Dichlorophenyl)-1′-(3,5-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2-spiro-2′-pyrrolizidine-3′-spiro-3′′-indoline-1,2′′-dione
por: Kamala, E. Theboral Sugi, et al.
Publicado: (2008)

Methyl 4′-benzyl-2,2′-dimethyl-1,3-dioxo-2,3-dihydro-1H,4′H-spiro[isoquinoline-4,5′-oxazole]-4′-carboxylate
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

Methyl 4′-isobutyl-2,2′-dimethyl-1,3-dioxo-2,3-dihydro-1H,4′H-spiro[isoquinoline-4,5′-oxazole]-4′-carboxylate
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

3′-(4-Chlorobenzoyl)-4′-(4-chlorophenyl)-1′-methylspiro[indoline-3,2′-pyrrolidin]-2-one
por: Srinivasan, T., et al.
Publicado: (2011)

Amination of 5-Spiro-Substituted 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones
por: Khramtsova, Ekaterina E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k612ak675o1v796i3dqrjopsbt