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Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Mole...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Eiji, Domański, Jan, Naughton, Fiona B., Best, Robert B., Kalli, Antreas C., Stansfeld, Phillip J., Sansom, Mark S. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030919/ https://www.ncbi.nlm.nih.gov/pubmed/32128410 http://dx.doi.org/10.1126/sciadv.aay5736

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