IRE1α kinase–mediated unconventional protein secretion rescues misfolded CFTR and pendrin

The most prevalent pathogenic mutations in the CFTR (ΔF508) and SLC26A4/pendrin (p.H723R), which cause cystic fibrosis and congenital hearing loss, respectively, evoke protein misfolding and subsequent defects in their cell surface trafficking. Here, we report that activation of the IRE1α kinase pat...

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Detalles Bibliográficos
Autores principales: Park, Hak, Shin, Dong Hoon, Sim, Ju-Ri, Aum, Sowon, Lee, Min Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030921/
https://www.ncbi.nlm.nih.gov/pubmed/32128399
http://dx.doi.org/10.1126/sciadv.aax9914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030921/
https://www.ncbi.nlm.nih.gov/pubmed/32128399
http://dx.doi.org/10.1126/sciadv.aax9914

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