Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide assoc...

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Detalles Bibliográficos
Autores principales: Klarić, Lucija, Tsepilov, Yakov A., Stanton, Chloe M., Mangino, Massimo, Sikka, Timo Tõnis, Esko, Tõnu, Pakhomov, Eugene, Salo, Perttu, Deelen, Joris, McGurnaghan, Stuart J., Keser, Toma, Vučković, Frano, Ugrina, Ivo, Krištić, Jasminka, Gudelj, Ivan, Štambuk, Jerko, Plomp, Rosina, Pučić-Baković, Maja, Pavić, Tamara, Vilaj, Marija, Trbojević-Akmačić, Irena, Drake, Camilla, Dobrinić, Paula, Mlinarec, Jelena, Jelušić, Barbara, Richmond, Anne, Timofeeva, Maria, Grishchenko, Alexander K., Dmitrieva, Julia, Bermingham, Mairead L., Sharapov, Sodbo Zh., Farrington, Susan M., Theodoratou, Evropi, Uh, Hae-Won, Beekman, Marian, Slagboom, Eline P., Louis, Edouard, Georges, Michel, Wuhrer, Manfred, Colhoun, Helen M., Dunlop, Malcolm G., Perola, Markus, Fischer, Krista, Polasek, Ozren, Campbell, Harry, Rudan, Igor, Wilson, James F., Zoldoš, Vlatka, Vitart, Veronique, Spector, Tim, Aulchenko, Yurii S., Lauc, Gordan, Hayward, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030929/
https://www.ncbi.nlm.nih.gov/pubmed/32128391
http://dx.doi.org/10.1126/sciadv.aax0301

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