Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC

BACKGROUNDS: p53 is a tumor suppressor that prevents cancer onset and progression, and mutations in the p53 gene cause loss of the tumor suppressor function of the protein. The mutant p53 protein in tumor cells can form aggregates which contribute to the dominant-negative effect over the wild-type p...

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Detalles Bibliográficos
Autores principales: Zhang, Yaqun, Xu, Lingfan, Chang, Yan, Li, YanJing, Butler, William, Jin, Er, Wang, Aifen, Tao, Yulei, Chen, Xufeng, Liang, Chaozhao, Huang, Jiaoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031025/
https://www.ncbi.nlm.nih.gov/pubmed/31471556
http://dx.doi.org/10.1038/s41391-019-0172-z

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