Early TP53 Alterations Engage Environmental Exposures to Promote Gastric Premalignancy in an Integrative Mouse Model

Somatic alterations in cancer genes are being detected in normal and premalignant tissue, placing greater emphasis on gene-environment interactions that enable disease phenotypes. By combining early genetic alterations with disease-relevant exposures, we developed an integrative mouse model to study...

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Detalles Bibliográficos
Autores principales: Sethi, Nilay S., Kikuchi, Osamu, Duronio, Gina, Stachler, Matthew D., McFarland, James M., Ferrer-Luna, Ruben, Zhang, Yanxi, Bao, Chunyang, Bronson, Roderick, Patil, Deepa, Sanchez-Vega, Francisco, Liu, Jie-Bin, Sicinska, Ewa, Lazaro, Jean-Bernard, Ligon, Keith L., Beroukhim, Rameen, Bass, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031028/
https://www.ncbi.nlm.nih.gov/pubmed/32025000
http://dx.doi.org/10.1038/s41588-019-0574-9

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