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Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis

OBJECTIVES: To explore the relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis (axSpA). METHODS: A convenience sample of 131 newly diagnosed axSpA patients and 60 healthy controls was recruited from July 2016 to December 2018....

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Autores principales: Deng, Sisi, He, Yi, Nian, Xinying, Sun, Erwei, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Nursing Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031124/
https://www.ncbi.nlm.nih.gov/pubmed/32099860
http://dx.doi.org/10.1016/j.ijnss.2019.12.005
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author Deng, Sisi
He, Yi
Nian, Xinying
Sun, Erwei
Li, Li
author_facet Deng, Sisi
He, Yi
Nian, Xinying
Sun, Erwei
Li, Li
author_sort Deng, Sisi
collection PubMed
description OBJECTIVES: To explore the relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis (axSpA). METHODS: A convenience sample of 131 newly diagnosed axSpA patients and 60 healthy controls was recruited from July 2016 to December 2018. Serum 25-hydroxyvitamin D [25(OH)D] was measured to assess vitamin D levels. Disease activity was assessed by objective indicators [Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the Bath Ankylosing Spondylitis Metrology Index (BASMI)], patient-reported questionnaires [the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and the Bath Ankylosing Spondylitis Functional Index (BASFI)]. Pain intensity and interference were also assessed. RESULTS: Vitamin D insufficiency [serum 25(OH) D levels<50 nmol/L]was found in 46 (35.1%) and 25 (43.3%) of the axSpA patients and the healthy controls, respectively. Female patients had higher risk (OR:4.928; 95% CI: 1.921–12.642) for vitamin D insufficiency than male patients. Vitamin D was positively correlated with CRP, ESR level, the BASFI, and the BASMI. Logistic regression showed that vitamin D levels were not associated with pain, or disease activity in the newly diagnosed axSpA patients. Gender was the only predictive variable for vitamin D levels. CONCLUSIONS: Vitamin D insufficiency was prevalent in both newly diagnosed axSpA patients and healthy controls. There was no association between vitamin D and pain and disease activity in the newly diagnosed axSpA patients. Monitoring vitamin D levels is important and early intervention for vitamin D insufficiency is needed, especially in female patients.
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spelling pubmed-70311242020-02-25 Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis Deng, Sisi He, Yi Nian, Xinying Sun, Erwei Li, Li Int J Nurs Sci Original Article OBJECTIVES: To explore the relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis (axSpA). METHODS: A convenience sample of 131 newly diagnosed axSpA patients and 60 healthy controls was recruited from July 2016 to December 2018. Serum 25-hydroxyvitamin D [25(OH)D] was measured to assess vitamin D levels. Disease activity was assessed by objective indicators [Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the Bath Ankylosing Spondylitis Metrology Index (BASMI)], patient-reported questionnaires [the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and the Bath Ankylosing Spondylitis Functional Index (BASFI)]. Pain intensity and interference were also assessed. RESULTS: Vitamin D insufficiency [serum 25(OH) D levels<50 nmol/L]was found in 46 (35.1%) and 25 (43.3%) of the axSpA patients and the healthy controls, respectively. Female patients had higher risk (OR:4.928; 95% CI: 1.921–12.642) for vitamin D insufficiency than male patients. Vitamin D was positively correlated with CRP, ESR level, the BASFI, and the BASMI. Logistic regression showed that vitamin D levels were not associated with pain, or disease activity in the newly diagnosed axSpA patients. Gender was the only predictive variable for vitamin D levels. CONCLUSIONS: Vitamin D insufficiency was prevalent in both newly diagnosed axSpA patients and healthy controls. There was no association between vitamin D and pain and disease activity in the newly diagnosed axSpA patients. Monitoring vitamin D levels is important and early intervention for vitamin D insufficiency is needed, especially in female patients. Chinese Nursing Association 2019-12-12 /pmc/articles/PMC7031124/ /pubmed/32099860 http://dx.doi.org/10.1016/j.ijnss.2019.12.005 Text en © 2020 Chinese Nursing Association. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Deng, Sisi
He, Yi
Nian, Xinying
Sun, Erwei
Li, Li
Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title_full Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title_fullStr Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title_full_unstemmed Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title_short Relationship between Vitamin D levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
title_sort relationship between vitamin d levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031124/
https://www.ncbi.nlm.nih.gov/pubmed/32099860
http://dx.doi.org/10.1016/j.ijnss.2019.12.005
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