Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies. TGF-β is strongly expressed in both the epithelial and stromal compartments of PDAC, and dysregulation of TGF-β signalling is a frequent molecular disturbance in PDAC progression and metastasis. In this study, we inv...

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Detalles Bibliográficos
Autores principales: Hong, Eunji, Park, Sujin, Ooshima, Akira, Hong, Chang Pyo, Park, Jinah, Heo, Jin Sun, Lee, Siyoung, An, Haein, Kang, Jin Muk, Park, Seok Hee, Park, Joon Oh, Kim, Seong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031242/
https://www.ncbi.nlm.nih.gov/pubmed/32076068
http://dx.doi.org/10.1038/s41598-020-59893-5

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