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Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-dimensiona...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031392/ https://www.ncbi.nlm.nih.gov/pubmed/32076031 http://dx.doi.org/10.1038/s41598-020-59803-9 |
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author | Zhang, Lu Li, Junjun Liu, Li Tang, Chao |
author_facet | Zhang, Lu Li, Junjun Liu, Li Tang, Chao |
author_sort | Zhang, Lu |
collection | PubMed |
description | Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-dimensional self-organized tissue rings. Within these rings, traveling waves of action potentials spontaneously originate and propagate for a long time. In order to understand the dynamic behavior of these waves, we developed a mathematical model for the circulation of the electrical signal in such rings. By using the restitution curves of the action potential and the conduction velocity we demonstrated the mechanisms underlying the steady circulation and the features dependent on velocity. The analytic result agreed well with the experimental data in the origination, propagation, and long-term behavior of traveling waves within self-organized tissue rings. The theoretical analysis of traveling waves may also provide a reference to the analysis of reentrant rhythms in hearts. |
format | Online Article Text |
id | pubmed-7031392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70313922020-02-27 Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells Zhang, Lu Li, Junjun Liu, Li Tang, Chao Sci Rep Article Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-dimensional self-organized tissue rings. Within these rings, traveling waves of action potentials spontaneously originate and propagate for a long time. In order to understand the dynamic behavior of these waves, we developed a mathematical model for the circulation of the electrical signal in such rings. By using the restitution curves of the action potential and the conduction velocity we demonstrated the mechanisms underlying the steady circulation and the features dependent on velocity. The analytic result agreed well with the experimental data in the origination, propagation, and long-term behavior of traveling waves within self-organized tissue rings. The theoretical analysis of traveling waves may also provide a reference to the analysis of reentrant rhythms in hearts. Nature Publishing Group UK 2020-02-19 /pmc/articles/PMC7031392/ /pubmed/32076031 http://dx.doi.org/10.1038/s41598-020-59803-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhang, Lu Li, Junjun Liu, Li Tang, Chao Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title | Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title_full | Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title_fullStr | Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title_full_unstemmed | Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title_short | Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells |
title_sort | analysis of circulating waves in tissue rings derived from human induced pluripotent stem cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031392/ https://www.ncbi.nlm.nih.gov/pubmed/32076031 http://dx.doi.org/10.1038/s41598-020-59803-9 |
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