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Cysteine redox state regulates human β2-adrenergic receptor binding and function

Bronchoconstrictive airway disorders such as asthma are characterized by inflammation and increases in reactive oxygen species (ROS), which produce a highly oxidative environment. β2-adrenergic receptor (β2AR) agonists are a mainstay of clinical therapy for asthma and provide bronchorelaxation upon...

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Detalles Bibliográficos
Autores principales: Rambacher, Kalyn M., Moniri, Nader H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031529/
https://www.ncbi.nlm.nih.gov/pubmed/32076070
http://dx.doi.org/10.1038/s41598-020-59983-4