A proof‐of‐concept study on the effects of low total cfDNA content and solutions to increase the NIPT trisomy 21 detection rate

BACKGROUND: Non‐invasive prenatal testing (NIPT) is routinely used in clinical practice for fetal trisomy screening, but low total cfDNA content and low fetal fraction (LFF) are two factors that affect the detection rate. Samples with low total cfDNA or LFF usually end up with “no‐call” results, fol...

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Detalles Bibliográficos
Autores principales: Du, Yang, Chen, Ailing, Yang, Rui, Zhou, Tao, Zhou, Qin, Yang, Lan, Wang, Juan, Hong, Yan, Chen, Chen, Wan, Qian, Yang, Lin, Chen, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031630/
https://www.ncbi.nlm.nih.gov/pubmed/31568605
http://dx.doi.org/10.1002/jcla.23035

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