Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

We report detailed susceptibility profiling of asexual blood stages of the malaria parasite Plasmodium falciparum to clinical and experimental antimalarials, combined with metabolomic fingerprinting. Results revealed a variety of stage-specific and metabolic profiles that differentiated the modes of...

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Detalles Bibliográficos
Autores principales: Murithi, James M., Owen, Edward S., Istvan, Eva S., Lee, Marcus C.S., Ottilie, Sabine, Chibale, Kelly, Goldberg, Daniel E., Winzeler, Elizabeth A., Llinás, Manuel, Fidock, David A., Vanaerschot, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031696/
https://www.ncbi.nlm.nih.gov/pubmed/31813848
http://dx.doi.org/10.1016/j.chembiol.2019.11.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031696/
https://www.ncbi.nlm.nih.gov/pubmed/31813848
http://dx.doi.org/10.1016/j.chembiol.2019.11.009

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